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首页> 外文期刊>Cytology and genetics >Allelic polymorphism C-590T of the IL4 gene as a probable genetic marker for the increased predisposition to the development of recurrent episodes of acute obstructive bronchitis in children
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Allelic polymorphism C-590T of the IL4 gene as a probable genetic marker for the increased predisposition to the development of recurrent episodes of acute obstructive bronchitis in children

机译：IL4基因的C-590T等位基因多态性可能是导致儿童急性阻塞性支气管炎反复发作的诱因

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摘要

Acute respiratory infections (ARIs) hold the first place among all infections throughout the world. ARIs are frequently complicated by the development of acute obstructive bronchitis (AOB). According to different authors, the frequency of developing AOB due to ARIs in children ranges from 5 to 40%. The growing occurrences of ARIs in children and the formation of bronchoobstructive syndrome that frequently ends up in the development of bronchial asthma, leading children to invalidity, specify a new priority research area-molecular genetic markers sought for to identify an increased predisposition to certain socially important illnesses. The molecular-genetic testing of the polymorphic C-590T locus of the IL4 gene as the marker of increased predisposition to the development of recurrent episodes of AOB were conducted in 31 children with frequent ARIs and recurrent episodes of AOB and in 50 general-population control subjects. The level of IgE in the blood serum was studied in 31 children with frequent recurrent episodes of AOB and compared with the data of 35 control children with acute bronchitis. The comparative molecular genetic analysis of the results in children with recurrent episodes of AOB and the data obtained from the subjects of a general population control group has shown that the frequency of the CT genotype at the polymorphic C-590T locus of the IL4 gene was noticeably higher in children with recurrent AOB episodes. The markedly higher frequency of the CC genotype at the polymorphic C-590T locus of the IL4 gene was recorded in the control group subjects and compared to the data of children from the main group. It was established that carrying the 590 CT genotype with the allelic polymorphism of the IL4 gene increases the risk of recurrent episodes of AOB in children by three times. The level of IgE in the blood serum in the majority of sick children from the main group was four times higher than in the control children.
机译：急性呼吸道感染（ARI）在全世界所有感染中排名第一。急性阻塞性支气管炎（AOB）的发展常常使ARIs复杂化。根据不同的作者，在儿童中由ARI引起的AOB发生频率为5％至40％。儿童中ARI的发生率不断上升，支气管阻塞综合症的形成经常导致支气管哮喘的发展，导致儿童致残，这是一个新的优先研究领域-分子遗传标志物，旨在鉴定对某些具有社会重要性的易感性疾病。对31例ARIs频繁发作和AOB复发的儿童以及50例普通人群的对照进行了IL4基因多态性C-590T位点的分子遗传学测试，作为增加AOB复发的易感性的标志物科目。研究了31例经常复发的AOB儿童的血清中IgE水平，并与35例急性支气管炎对照儿童的数据进行了比较。对AOB复发儿童的结果进行的比较分子遗传学分析以及从一般人群对照组的受试者获得的数据表明，IL4基因多态C-590T位点的CT基因型频率显着复发性AOB发作的儿童较高。在对照组受试者中记录了IL4基因多态性C-590T基因座上CC基因型的显着较高频率，并将其与主要儿童的数据进行了比较。已确定携带590 CT基因型和IL4基因的等位基因多态性可使儿童发生AOB复发的风险增加三倍。大多数主要患病儿童的血清中IgE水平是正常儿童的四倍。

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