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Bcl1 polymorphism of glucocorticoid receptor gene in patients with bronchial asthma with obesity

机译：肥胖性支气管哮喘患者糖皮质激素受体基因的Bcl1多态性

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摘要

The objective of this investigation was to analyze possible association between Bcl1 polymorphism of glucocorticoid receptor gene and obesity in patients with bronchial asthma (BA). The study involved 188 patients with bronchial asthma and 95 apparently healthy adult individuals. Generally accepted assessments and examinations for BA diagnosis, and anthropometric, molecular-genetic and statistic methods of investigation were used in the research. It was found out that the patients with BA demonstrated higher body mass index (BMI) and higher ratio of fat centralization much more often, than the control group. Genotypes distribution for Bcl1 polymorphism in patients with BA showed a statistically significant difference between patients with different BMI unlike the control group. Comparison of genotype frequency for Bcl1 polymorphism in glucocorticoid receptor gene in individuals with different ratio of fat centralization in the control group and in the patients with BA separately showed statistically significant differences in the distribution of gene allelic variations only among the patients with BA. It was demonstrated that G/G genotype in the patients with visceral obesity was associated with BA.
机译：这项研究的目的是分析糖皮质激素受体基因的Bcl1多态性与支气管哮喘（BA）患者的肥胖之间的可能联系。该研究涉及188名支气管哮喘患者和95名显然健康的成年人。本研究采用了公认的BA诊断评估和检查方法，以及人体测量学，分子遗传学和统计学方法。结果发现，与对照组相比，BA患者表现出更高的体重指数（BMI）和更高的脂肪集中率。 BA组患者Bcl1基因多态性的基因型分布与对照组相比，不同BMI患者之间的统计学差异有统计学意义。在对照组和BA患者中，不同脂肪集中率的个体中糖皮质激素受体基因Bcl1多态性的基因型频率比较分别显示在BA患者中基因等位基因变异的分布具有统计学意义。证实内脏型肥胖患者的G / G基因型与BA相关。

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