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首页> 外文期刊>Cytology and genetics >IL1β, IL6 and IL8 Gene Polymorphisms Involvement in Recurrent Corneal Erosion in Patients with Hereditary Stromal Corneal Dystrophies
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IL1β, IL6 and IL8 Gene Polymorphisms Involvement in Recurrent Corneal Erosion in Patients with Hereditary Stromal Corneal Dystrophies

机译：IL1β，IL6和IL8基因多态性与遗传性间质性角膜营养不良患者复发性角膜侵蚀的关系

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摘要

Tgfbl gene mutations cause corneal stromal dystrophies of autosomal dominant inheritance. The most frequent complication of stromal dystrophies is recurrent corneal erosion with varying degree of accompanying inflammation. IL-1, IL-6 and IL-8 are main cytokines involved in corneal erosion healing. This study aimed to investigate the association between IL IB gene -511C/T, IL6 gene -174G/C and IL8 gene -781C/T polymorphisms and risk of recurrent erosion development in patients with hereditary corneal stromal dystrophies. A trend to decrease of IL1B gene —511TT genotype frequency in group with erosion (3.7%) comparing to control (6.7%) was observed. IL6 gene — 174C allele carriers frequency in control group (65.9%) was significantly (P < 0.05) lower comparing to patients with erosion (80.5%). Frequency of IL8 -781TT genotype was significantly (P < 0.05) lower in the group with erosion (10.7%) comparing to patients without erosion (30.8%) and control (25%). IL6 gene — 174C allele may be considered as genetic marker of corneal erosion risk in patients with hereditary stromal corneal dystrophies, whereas IL8 -781TT genotype is associated with negative recurrent erosion prognosis in such patients.
机译：Tgfbl基因突变导致常染色体显性遗传的角膜基质营养不良。基质营养不良最常见的并发症是复发性角膜糜烂，并伴有不同程度的伴随炎症。 IL-1，IL-6和IL-8是参与角膜糜烂愈合的主要细胞因子。本研究旨在探讨遗传性角膜基质营养不良患者IL IB基因-511C / T，IL6基因-174G / C和IL8基因-781C / T多态性与复发性糜烂风险的关系。与对照组（6.7％）相比，侵蚀组（3.7％）的IL1B基因-511TT基因型频率减少趋势。对照组中，IL6基因— 174C等位基因携带者频率（65.9％）明显低于糜烂患者（80.5％）（P <0.05）。与无糜烂组（30.8％）和对照组（25％）相比，有糜烂组（10.7％）的IL8 -781TT基因型频率显着降低（P <0.05）。 IL6基因— 174C等位基因可能被认为是遗传性间质性角膜营养不良患者角膜糜烂风险的遗传标记，而IL8 -781TT基因型与这类患者复发性糜烂预后相关。

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  • 来源
    《Cytology and genetics》 |2013年第3期|164-166|共3页
  • 作者

    A. M. Kucherenko; V. M. Pampukha; G. I. Drozhzhyna; L. A. Livshits;

  • 作者单位

    Institute of Molecular Biology and Genetics of the National Academy of Sciences of Ukraine, Kyiv,Taras Shevchenko National University of Kyiv, Educational and Scientific Centre "Institute of Biology";

    Institute of Molecular Biology and Genetics of the National Academy of Sciences of Ukraine, Kyiv;

    SI "The Filatov Institute of Eye Diseases and Tissue Therapy, AMS of Ukraine", Odessa;

    Institute of Molecular Biology and Genetics of the National Academy of Sciences of Ukraine, Kyiv;

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