...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytology and genetics >Heterologous Expression of the lndYR and wblA_(gh) Genes in Streptomyces nogalater LV65, S. echinatus DSM40730, and S. peucetius Subsp. Caesius ATCC27952 (Producers of Anthracycline Antibiotics)
【24h】

Heterologous Expression of the lndYR and wblA_(gh) Genes in Streptomyces nogalater LV65, S. echinatus DSM40730, and S. peucetius Subsp. Caesius ATCC27952 (Producers of Anthracycline Antibiotics)

机译：lndYR和wblA_（gh）基因在链霉菌LV65，紫锥菊（S. echinatus DSM40730）和S.peucetius Subsp。中的异源表达。 Caesius ATCC27952（蒽环类抗生素的生产者）

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Strains of the actinomycetes Streptomyces nogalater Lv65, S. echinatus DSM40730, and S. peucetius subsp. caesius ATCC27952 are producers of the anthracycline antibiotics nogalamycin, aranciamycin, and doxorubicin, respectively. This work was focused on the impact produced by the expression of the regulatory lndYR and wblA_(gh) genes on the secondary metabolism and morphogenesis of these bacteria. Introducing regulators into the composition of replicative plasmids in the streptomycetes in question leads to a decrease in the synthesis of anthracyclines, whereas the expression of lndYR in cells of S. peucetius subsp. caesius ATCC27952 suppresses the sporulation of the doxorubicin producer which may indicate the presence of their homologues in the genomes. The identification of these genes for the purpose of their further directed inactivation may be a successful tool for obtaining strains with an increased level of synthesis of clinically important compounds, as well as it can allow us to establish particular stages in the regulation of the secondary metabolism of anthracycline antibiotics.
机译：放线菌菌株Streptomyces nogalater Lv65，紫锥菊DSM40730和S.peucetius亚种。 caesius ATCC27952分别是蒽环类抗生素诺加霉素，阿那霉素和阿霉素的生产商。这项工作的重点是调节性lndYR和wblA_（gh）基因的表达对这些细菌的次级代谢和形态发生产生的影响。将调节剂引入所讨论的链霉菌中的复制质粒的组成中导致蒽环类抗生素的合成减少，而ldnYR在peucetius亚种中的表达。 caesius ATCC27952抑制了阿霉素生产者的孢子形成，这可能表明它们在基因组中存在同系物。为进一步定向失活而鉴定这些基因可能是获得具有重要临床意义化合物合成水平的菌株的成功工具，并且可以使我们在二级代谢调节中建立特定阶段蒽环类抗生素。

著录项

相似文献

  • 外文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号