Reconstruction of the Spatial Structure of Plant Phosphatases Types 1 and 2A in Complexes with Okadaic Acid

D. A. Samofalova; P. A. Karpov; A. Yu. Nuporko; Ya. B. Blume

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Reconstruction of the Spatial Structure of Plant Phosphatases Types 1 and 2A in Complexes with Okadaic Acid

机译：冈田酸配合物中植物磷酸酶1和2A型空间结构的重建

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Homology modeling based on the known spatial structures of Homo sapiens protein phosphatases types 1 and 2A was implemented. The spatial structures of human protein phosphatases and their plant homologs from Arabidopsis thaliana were predicted. The quality of the models was confirmed by the root mean square deviations of the atoms and conformational analysis results. The sites of okadaic acid bindings in the molecules of plant protein phosphatases (types 1 and 2A) were verified by the data of comparative analyses and molecular dynamics.

机译：根据智人蛋白质磷酸酶1和2A型的已知空间结构，进行了同源性建模。预测了拟南芥人蛋白磷酸酶的空间结构及其植物同源物。通过原子的均方根偏差和构象分析结果确认了模型的质量。通过比较分析和分子动力学数据验证了植物蛋白磷酸酶（1型和2A型）分子中冈田酸结合的位点。

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《Cytology and genetics》 |2011年第3期|p.153-162|共10页
作者
D. A. Samofalova; P. A. Karpov; A. Yu. Nuporko; Ya. B. Blume;
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Institute of Food Biotechnology and Genomics, Ukrainian National Academy of Sciences, Kiev, Ukraine;

Institute of Food Biotechnology and Genomics, Ukrainian National Academy of Sciences, Kiev, Ukraine;

Institute of Food Biotechnology and Genomics, Ukrainian National Academy of Sciences, Kiev, Ukraine;

Institute of Food Biotechnology and Genomics, Ukrainian National Academy of Sciences, Kiev, Ukraine;

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1. Essential Role of Protein Phosphatase 2A in Metaphase II Arrest and Activation of Mouse Eggs Shown by Okadaic Acid, Dominant Negative Protein Phosphatase 2A, and FTY720 [J] . Heng-Yu Chang, Phoebe Jennings, Jessica Stewart, The Journal of biological chemistry . 2011,第16期

机译：冈田酸，显性负蛋白磷酸酶2a和FTY720所示的蛋白质磷酸酶2a在Metaphase II停滞和激活的基本作用
2. Inhibition by calyculin A and okadaic acid of the Ca2+ release-activated Ca2+ entry pathway in rat basophilic leukemia cells: Evidence for regulation by Type 1/2A serine/threonine phosphatase activity [J] . Evans NE, Forth MKL, Simpson AK, Biochimica et biophysica acta. Biomembranes . 2005,第1a2期

机译：Calyculin A和冈田酸对大鼠嗜碱性白血病细胞中Ca2 +释放激活的Ca2 +进入途径的抑制：1 / 2A型丝氨酸/苏氨酸磷酸酶活性调节的证据
3. Estimation of the rate constants associated with the inhibitory effect of okadaic acid on type 2A protein phosphatase by time-course analysis [J] . A Takai, G Mieskes, T Yasumoto, The biochemical journal . 1992,第1期

机译：通过时程分析估算与冈田酸对2A型蛋白磷酸酶抑制作用相关的速率常数
4. Phosphate-starvation response of cereal plants: acid phosphatase activity and growth changes [C] . . 2005

机译：谷物植物的磷饥饿反应：酸性磷酸酶活性和生长变化
5. Refining the pharmacophore for phosphatase inhibition and structure-based design of okadaic acid analogs. [D] . Colby, David Alan. 2006

机译：完善药效基团对磷酸酶的抑制作用和冈田酸类似物的基于结构的设计。
6. Okadaic acid a potent inhibitor of type 1 and type 2A protein phosphatases activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells. [O] . K Yamashita, H Yasuda, J Pines, 1990

机译：冈田酸是1型和2A型蛋白磷酸酶的有效抑制剂可激活cdc2 / H1激酶并在BHK21细胞中短暂诱导过早的有丝分裂样状态。
7. Reconstruction of spatial structure of plant protein phosphatase type 1, 2a and 4 in complexes with microcystin-LR [O] . D. A. Samofalova, P. A. Karpov, O. V. Raievskyi, 1970

机译：植物蛋白磷酸酶1,2A和4中的微囊藻 - LR重建植物蛋白磷酸酶的空间结构
8. Differentiation, early response gene expression, and apoptosis induction in human breast tumor cells by Okadaic Acid and related inhibitors of protein phosphatases 1 and 2A. Okadaic acid effects on human breast tumor cells [R] . Kiguchi, K. , Giometti, C. , Chubb, C. H. , 1992

机译：冈田酸和蛋白磷酸酶1和2a的相关抑制剂在人乳腺肿瘤细胞中的分化，早期反应基因表达和凋亡诱导。冈田酸对人乳腺癌细胞的影响

Reconstruction of the Spatial Structure of Plant Phosphatases Types 1 and 2A in Complexes with Okadaic Acid

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