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Effect of Avermectin on the Ultrastructural Characteristics of Loach Embryos

机译:阿维菌素对泥ach胚超微结构特征的影响

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摘要

The infrastructure of loach (Misgurnus fossilis L.) embryo cells at the stages of the first and tenth blastomere divisions in the presence of avermectin B (a compound that belongs to the class of macrocyclic lactones, avermectins) in an incubation medium at concentrations of 0.01,0.1, and 1.0 ug/ml was studied. It was found that the effect of this compound led to ultrastructural changes in cell organelles, such as hypertrophy of the granular and agranular endoplasmic reticulum and disorganization of the mitochondria and the embryo plasma membrane. Avermectin activity causes dose-dependent destructive changes in organelles; such changes are the consequences of the destruction of metabolic and regulatory processes, caused by the inhibitory influence of avermectin on the processes of active transport of Na~+, K~+ and Ca~(2+) ions. The data obtained in this study show that avermectin is characterized by high embryotoxicity.
机译:在浓度为0.01的温育培养基中存在阿维菌素B(一种属于大环内酯类化合物,阿维菌素)的第一卵裂球和第十卵裂球分裂阶段的泥ach(Misgurnusiferis L.)胚胎细胞的基础结构研究了0.1、1.0和1.0ug / ml。发现该化合物的作用导致细胞器的超微结构改变,例如颗粒状和颗粒状内质网的肥大以及线粒体和胚胎质膜的混乱。阿维菌素活性引起细胞器剂量依赖性破坏性改变;这种变化是由于阿维菌素对Na〜+,K〜+和Ca〜(2+)离子的主动转运过程的抑制作用所引起的代谢和调节过程破坏的结果。这项研究获得的数据表明,阿维菌素的特征是具有高胚胎毒性。

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  • 来源
    《Cytology and genetics》 |2011年第5期|p.318-323|共6页
  • 作者单位

    Franko National University of Lviv, st. Universytetska I, Lviv, 79000 Ukraine;

    Franko National University of Lviv, st. Universytetska I, Lviv, 79000 Ukraine;

    Franko National University of Lviv, st. Universytetska I, Lviv, 79000 Ukraine;

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