Notch~(122), Mutation of Abruptex-Type Notch Locus in Drosophila virilis: Peculiarities of Genetic Interactions

I. S. Gubenko; R. P. Subbota; E. S. Zelentsova

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Notch~(122), Mutation of Abruptex-Type Notch Locus in Drosophila virilis: Peculiarities of Genetic Interactions

机译：Notch〜（122），果蝇中Abruptex型Notch位点的突变：遗传相互作用的特殊性

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The nature and functional peculiarities of Abruptex-type Notch alleles are not yet known. A high level of phenotypic allele polymorphism has been found in Drosophila in known Abruptex lines. In addition to mutants with a lack of Notch function, there are hypomorphic, hypermorphic, and antimorphic alleles that often show enhanced cell proliferation and the failure of processes of cell differentiation in wings. It is considered that Abruptex alleles can serve as a model for studying the reasons for and consequences of hereditary diseases in humans, including CADASIL, which, as is supposed, is related to modifications in Notch activity and gene interactions in the Notch signal system.

机译：还不清楚Abruptex型Notch等位基因的性质和功能特性。在果蝇中，在已知的Abruptex品系中发现了高水平的表型等位基因多态性。除缺少Notch功能的突变体外，还有亚型，亚型和反型等位基因，这些等位基因通常显示细胞增殖增强，翅膀中细胞分化过程失败。人们认为Abruptex等位基因可以作为研究人类遗传疾病的原因和后果的模型，其中包括CADASIL，据推测，这与Notch信号系统中Notch活性的改变和基因相互作用有关。

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《Cytology and genetics》 |2010年第3期|P.170-173|共4页
作者
I. S. Gubenko; R. P. Subbota; E. S. Zelentsova;
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Institute of Molecular Biology and Genetics, Ukrainian National Academy of Sciences, Kiev, Ukraine;

rnInstitute of Molecular Biology and Genetics, Ukrainian National Academy of Sciences, Kiev, Ukraine;

rnInstitute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia;

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1. IS THE NOTCH LOCUS OF DROSOPHILA MELANOGASTER A TANDEM REPEAT? CORRELATION OF THE GENETIC MAP AND COMPLEMENTATION PATTERN OF SELECTED MUTATIONS [J] . Geoffrey G. Foster Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 1973,第3期

机译：果蝇黑斑病是串联重复吗？遗传图谱与选定突变的互补模式的相关性
2. E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia. [J] . Pereira PS, Teixeira A, Pinho S, Human Molecular Genetics . 2006,第10期

机译：E-钙黏着蛋白错义突变与遗传性弥漫性胃癌（HDGC）综合征相关联，表现出与果蝇上皮细胞Wnt和Notch途径不同的侵袭行为和遗传相互作用。
3. E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia [J] . Paulo S. Pereira, †, Alexandra Teixeira, Human Molecular Genetics . 2006,第10期

机译：E-钙黏着蛋白错义突变，与遗传性弥漫性胃癌（HDGC）综合征相关联，显示果蝇上皮细胞不同的侵袭行为和与Wnt和Notch通路的遗传相互作用。
4. The Peculiarities of Crack Development in Chevron-Notched Specimens of ZrO_2 + 3 Y_2O_3 Ceramics [C] . E. E. Deryugin, V. E. Panin, G. V. Lasko, International Conference on Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures . 2018

机译：ZrO_2 + 3％Y_2O_3陶瓷的人脚轮 - 缺口标本中裂纹开发的特性
5. A genetic screen for modulators of the Notch pathway in Drosophila melanogaster identifies NOT1 as a positive regulator of Notch signaling. [D] . Morreale, Eric J. 2009

机译：对果蝇Notch途径调节剂的遗传筛选确定NOT1为Notch信号的正调节剂。
6. Is the Notch Locus of DROSOPHILA MELANOGASTER a Tandem Repeat? Correlation of the Genetic Map and Complementation Pattern of Selected Mutations [O] . Geoffrey G. Foster 1973

机译：DROSOPHILA MELANOGASTER的刻痕位点是否重复串联？选定突变的遗传图谱和互补模式的相关性
7. Notch122, мутация локуса Notch типа Abruptex у Drosophila virilis: особенности генетических взаимодействий [O] . Губенко И.С., Суббота Р.П., Зеленцова Е.С. 2010

机译：Notch122，果蝇中Abruptex型Notch基因座的突变：遗传相互作用的特征

Notch~(122), Mutation of Abruptex-Type Notch Locus in Drosophila virilis: Peculiarities of Genetic Interactions

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