• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytology and genetics >Grandmaternal Ages at Birth of Parents of Children with Down Syndrome in St. Petersburg
【24h】

Grandmaternal Ages at Birth of Parents of Children with Down Syndrome in St. Petersburg

机译：圣彼得堡唐氏综合症患儿父母的出生祖母年龄

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Data on the age of grandparents of 243 children with Down syndrome (DS) born between 1990 and 1999 are considered in this work in comparison with control families of 330 healthy children. In 102 fam ilies, where the age of the mother at the birth of a child with DS was younger 30 (or less than 30) years, the median ages of both maternal and paternal grandmothers of probands were actually the same (26 years). Actually, the median age of grandmothers in 226 young families having healthy children were also the same (27 years). No differences in the indicators in question were revealed between 141 families with DS and 104 families with healthy children, where the mothers were older than 29 years. Thus, our results have not confirmed the hypothesis about the influence of the age of DS probands' grandmothers on the segregation of chromosomes in their daughters' oogenesis, as well as the hypothesis about a significant contribution of the inherited trisomy of chromosome 21 to the frequency of DS in the general population.
机译：与330名健康儿童的对照组相比，这项工作考虑了1990年至1999年之间出生的243名唐氏综合症（DS）患儿的祖父母年龄数据。在102个家庭中，DS患儿的母亲的出生年龄小于30岁（或小于30岁），而先证者的祖母和祖母的中位年龄实际上是相同的（26岁）。实际上，在226个拥有健康孩子的年轻家庭中，祖母的中位年龄也相同（27岁）。在141个患有DS的家庭和104个健康孩子的母亲之间，相关指标没有发现差异，这些母亲的年龄均超过29岁。因此，我们的结果尚未证实关于DS先证者祖母的年龄对其女儿的卵子发育中染色体分离的影响的假设，以及关于21号染色体遗传三体性对频率的重大贡献的假设。 DS在一般人群中的比例。

著录项

  • 来源
    《Cytology and genetics》 |2010年第5期|p.300-305|共6页
  • 作者

    N. V. Kovaleva; M. Tahmasebi-Hesari; D. K. Verlinskaya;

  • 作者单位

    St. Petersburg State Pediatric Medical Academy, St. Petersburg, Russia;

    rnSt. Petersburg Medical Academy for Postgraduate Studies, St. Petersburg, Russia;

    rnSt. Petersburg Medical Genetic Diagnostic Center, St. Petersburg, Russia;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号