Graves' Disease: Hereditary Peculiarities and Effect of Selection on Its Prevalence Population

S.A. Shtandel; I. V. Gopkalova; V. V. Khaziev; V. N. Dubovik; E.A. Svetlova-Kovalenko

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Graves' Disease: Hereditary Peculiarities and Effect of Selection on Its Prevalence Population

机译：格雷夫斯病：遗传特质及其选择对其流行人群的影响

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The features of genetic determination and natural selection of diffuse toxic goiter (DTG) are studied on the basis of the clinical and genealogical data obtained from 242 patients with thyrotoxicosis and from obstetric anamneses of 2105 healthy women and 369 women with thyrotoxicosis. On the basis of the results of genetic analysis, the conformity of thyrotoxicosis inheritance to the alternative model parameters is revealed. In this model, the penetrance of homozygotes was 78.8%, and the penetrance of heterozygotes was 17.3%. It is shown that, in the population of Kharkiv oblast, the frequency of the gene of predisposition to thyrotoxicosis has grown 0.8% per generation.

机译：根据从242名甲状腺毒症患者和2105名健康女性和369名甲状腺毒症女性的产科回忆中获得的临床和家谱数据，研究了弥散性毒性甲状腺肿（DTG）的遗传测定和自然选择特征。根据遗传分析的结果，揭示了甲状腺毒症遗传与替代模型参数的一致性。在该模型中，纯合子的渗透率为78.8％，杂合子的渗透率为17.3％。结果表明，在哈尔科夫州人口中，易患甲状腺毒症的基因的发生率每代增长了0.8％。

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《Cytology and genetics》 |2009年第2期|126-131|共6页
作者
S.A. Shtandel; I. V. Gopkalova; V. V. Khaziev; V. N. Dubovik; E.A. Svetlova-Kovalenko;
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Danilevskii Institute of Endocrine Pathology Problems, Ukrainian Academy of Medical Sciences, vul. Artema 10, Kharkiv, 61002 Ukraine;

Danilevskii Institute of Endocrine Pathology Problems, Ukrainian Academy of Medical Sciences, vul. Artema 10, Kharkiv, 61002 Ukraine;

Danilevskii Institute of Endocrine Pathology Problems, Ukrainian Academy of Medical Sciences, vul. Artema 10, Kharkiv, 61002 Ukraine;

Danilevskii Institute of Endocrine Pathology Problems, Ukrainian Academy of Medical Sciences, vul. Artema 10, Kharkiv, 61002 Ukraine;

Danilevskii Institute of Endocrine Pathology Problems, Ukrainian Academy of Medical Sciences, vul. Artema 10, Kharkiv, 61002 Ukraine;

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Graves' Disease: Hereditary Peculiarities and Effect of Selection on Its Prevalence Population

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