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首页> 外文期刊>Cytology and genetics >Studying the Role of Protein Kinases CK1 in Organization of Cortical Microtubules in Arabidopsis thaliana Root Cells
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Studying the Role of Protein Kinases CK1 in Organization of Cortical Microtubules in Arabidopsis thaliana Root Cells

机译：研究蛋白激酶CK1在拟南芥中皮质微管组织中的作用

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摘要

The members of the casein kinase 1 (CK1) subfamily are distinguished by interspecific conservatism and an extensive set of phosphorylation substrates. Recently, appeared strong evidence that CK1 are able to phosphorylate tubulin directly. Thus, CK1 contribute to the tubulin code and functional specialization of microtubules. In this work, we present the results of studying the response of plant tubulin cytoskeleton to the treatment with the CK1-specific inhibitor D4476. It was demonstrated that D4476 shows a strong dose-dependent effect on Arabidopsis thaliana root growth and morphology. The experiments on the plants expressing chimeric gfp-map4 gene construct proved the relation of the observed morphological reactions with the spatial organization of microtubules caused by a selective inhibition of protein kinases CK1.
机译：酪蛋白激酶1（CK1）亚家族的成员通过各特异性的保守主义和大量的磷酸化基材来区分。最近，似乎有强的证据表明CK1能够直接磷酸化管蛋白。因此，CK1有助于微管蛋白代码和微管的功能专业化。在这项工作中，我们介绍了使用CK1特异性抑制剂D4476研究植物管蛋白细胞蛋白细胞骨架对处理的响应的结果。据证明D4476对拟南芥根系生长和形态显示出强烈的剂量依赖性影响。表达嵌合GFP-MAP4基因构建体的植物的实验证明了观察到的形态反应与由蛋白激酶CK1的选择性抑制引起的微管的空间组织的关系。

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