Tlr2 and Tjp1 Genes' Expression during Restoration of Skin Integrity

Huet A.; Dvorshchenko K.; Taburets O.; Grebinyk D.; Beregova T.; Ostapchenko L.

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Tlr2 and Tjp1 Genes' Expression during Restoration of Skin Integrity

机译：TLR2和TJP1基因在恢复皮肤完整性期间的表达

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摘要

Decrease in Tjp 1 gene expression against the background of the activation of free radical processes (increase in the content of superoxide anion-radical) was observed during full-thickness skin wounds' healing in rats. The restoration of the expression level of this gene may be mediated by an increase in the expression level of the Tlr2 gene. The level of Tjp1 gene expression, as well as the content of the superoxide anion radical, was closer to the control values at the specified wound pattern in the absence of the Tlr2 gene overexpression upon the treatment with melanin during restoration of skin integrity.

机译：在大鼠全厚的皮肤伤口愈合期间观察到对自由基过程的激活的背景（超氧化物阴离子含量的增加）降低TJP 1基因表达。该基因的表达水平的恢复可以通过增加TLR2基因的表达水平的增加来介导。 TJP1基因表达的水平以及超氧化物阴离子自由基的含量，在没有TLR2基因过表达的情况下在恢复皮肤完整性期间在用黑色素的情况下没有造成的TLR2基因过表达，在特定伤口模式下更接近对照值。

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来源
《Cytology and genetics》 |2020年第6期|539-545|共7页
作者
Huet A.; Dvorshchenko K.; Taburets O.; Grebinyk D.; Beregova T.; Ostapchenko L.;
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Taras Shevchenko Natl Univ Kyiv Inst Biol & Med Educ & Sci Ctr UA-01601 Kiev Ukraine;

Taras Shevchenko Natl Univ Kyiv Inst Biol & Med Educ & Sci Ctr UA-01601 Kiev Ukraine;

Taras Shevchenko Natl Univ Kyiv Inst Biol & Med Educ & Sci Ctr UA-01601 Kiev Ukraine;

Taras Shevchenko Natl Univ Kyiv Inst Biol & Med Educ & Sci Ctr UA-01601 Kiev Ukraine;

Taras Shevchenko Natl Univ Kyiv Inst Biol & Med Educ & Sci Ctr UA-01601 Kiev Ukraine;

Taras Shevchenko Natl Univ Kyiv Inst Biol & Med Educ & Sci Ctr UA-01601 Kiev Ukraine;

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正文语种 eng
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Tjp 1 and Tlr2 gene expression; full-thickness skin wounds; melanin;

机译：TJP 1和TLR2基因表达;全厚的皮肤伤口;黑色素;

Tlr2 and Tjp1 Genes' Expression during Restoration of Skin Integrity

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