...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Dental materials >Bioactive amorphous magnesium phosphate-polyetheretherketone composite filaments for 3D printing
【24h】

Bioactive amorphous magnesium phosphate-polyetheretherketone composite filaments for 3D printing

机译：生物活性无定形镁磷酸 - 聚醚醚酮酮复合丝，用于3D印刷

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective. The aim of this study was to develop bioactive and osseointegrable polyetheretherketone (PEEK)-based composite filaments melt-blended with novel amorphous magnesium phosphate (AMP) particles for 3D printing of dental and orthopedic implants.Materials and methods. A series of materials and biological analyses of AMP-PEEK were performed. Thermal stability, thermogravimetric and differential scanning calorimetry curves of as-synthesized AMP were measured. Complex viscosity, elastic modulus and viscous modulus were determined using a rotational rheometer. In vitro bioactivity was analyzed using SBF immersion method. SEM, EDS and XRD were used to study the apatite-forming ability of the AMP-PEEK filaments. Mouse pre-osteoblasts (MC3T3-E1) were cultured and analyzed for cell viability, proliferation and gene expression. For in vivo analyses, bare PEEK was used as the control and 15AMP-PEEK was chosen based on its in vitro cell-related results. After 4 or 12 weeks, animals were euthanized, and the femurs were collected for micro-computed tomography (mu-CT) and histology.Results. The collected findings confirmed the homogeneous dispersion of AMP particles within the PEEK matrix with no phase degradation. Rheological studies demonstrated that AMP-PEEK composites are good candidates for 3D printing by exhibiting high zero-shear and low infinite-shear viscosities. In vitro results revealed enhanced bioactivity and superior pre-osteoblast cell function in the case of AMP-PEEK composites as compared to bare PEEK. In vivo analyses further corroborated the enhanced osseointegration capacity for AMP-PEEK implants.Significance. Collectively, the present investigation demonstrated that AMP-PEEK composite filaments can serve as feedstock for 3D printing of orthopedic and dental implants due to enhanced bioactivity and osseointegration capacity. (C) 2020 The Academy of Dental Materials. Published by Elsevier Inc. All rights reserved.
机译：客观的。本研究的目的是开发生物活性和骨环可聚持的聚醚醚酮（PEEK）的基础复合丝，与新型无定形磷酸镁（AMP）颗粒混合，用于3D牙科和整形外科植入物的3D印刷。材料和方法。进行了一系列材料和amp-peek的生物学分析。测量了AS合成放大器的热稳定性，热标测和差示扫描量热法曲线。使用旋转流变仪测定复合粘度，弹性模量和粘性模量。使用SBF浸渍法分析体外生物活性。 SEM，EDS和XRD用于研究AMP-PEEK长丝的磷灰石形成能力。培养小鼠预成骨细胞（MC3T3-E1）并分析细胞活力，增殖和基因表达。对于体内分析，裸PEEK被用作对照，基于其与体外细胞相关结果选择15AMP-PEEK。在4或12周后，将动物安乐死，股骨被收集用于微计算断层扫描（MU-CT）和组织学。结果。收集的结果证实了放大器颗粒在PEEK基质内的均匀分散，没有相降次。流变研究证明，通过表现出高零剪和低无限剪切粘度，AMP-PEEK复合材料是3D打印的良好候选者。在与裸PEEK相比，在体外结果显示在AMP-PEEK复合材料的情况下提高了生物活性和优异的预成骨细胞功能。体内分析进一步证实了AMP-PEEK植入物的增强的骨整合能力。重要性。集体，本研究表明，由于增强的生物活性和骨整合能力，AMP-PEEK复合长丝可用作矫形和牙科植入物的3D印刷原料。 （c）2020牙科材料学院。由elsevier Inc.出版的所有权利保留。

著录项

  • 来源
    《Dental materials》 |2020年第7期|865-883|共19页
  • 作者

    Sikder Prabaha; Ferreira Jessica A.; Fakhrabadi Ehsan Akbari; Kantorski Karla Z.; Liberatore Matthew W.; Bottino Marco C.; Bhaduri Sarit B.;

  • 作者单位

    Univ Toledo Dept Mech Ind & Mfg Engn Toledo OH 43606 USA;

    Univ Michigan Sch Dent Dept Cariol Restorat Sci & Endodont 1011N Univ Room 5223 Ann Arbor MI 48109 USA;

    Univ Toledo Dept Chem Engn Toledo OH 43606 USA;

    Univ Michigan Sch Dent Dept Cariol Restorat Sci & Endodont 1011N Univ Room 5223 Ann Arbor MI 48109 USA|Univ Fed Santa Maria Sch Dent Postgrad Program Oral Sci Periodontol Unit Santa Maria RS Brazil;

    Univ Toledo Dept Chem Engn Toledo OH 43606 USA;

    Univ Michigan Sch Dent Dept Cariol Restorat Sci & Endodont 1011N Univ Room 5223 Ann Arbor MI 48109 USA;

    Univ Toledo Dept Mech Ind & Mfg Engn Toledo OH 43606 USA|Natl Sci Fdn EEC Div Directorate Engn Alexandria VA 22314 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Polyetheretherketone; Amorphous magnesium phosphate; 3D printing; Implants; Osseointegration;

    机译：聚醚醚酮;无定形磷酸镁;3D打印;植入物;骨整合;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号