Nonanimal Sourced Hyaluronic Acid–Based Dermal Filler Using a Cohesive Polydensified Matrix Technology is Superior to Bovine Collagen in the Correction of Moderate to Severe Nasolabial Folds: Results from a 6-Month, Randomized, Blinded, Controlled, Multicenter Study

RHODA S. NARINS MD; WILLIAM COLEMAN III MD; LISA DONOFRIO MD; DEREK H. JONES MD; COREY MAAS MD; GARY MONHEIT MD; MANDEEP KAUR MD; STARR L. GRUNDY BSC PHARM; ERIC J. PAPPERT MD; BHUSHAN HARDAS MD PHD

首页> 外文期刊>Dermatologic Surgery >Nonanimal Sourced Hyaluronic Acid–Based Dermal Filler Using a Cohesive Polydensified Matrix Technology is Superior to Bovine Collagen in the Correction of Moderate to Severe Nasolabial Folds: Results from a 6-Month, Randomized, Blinded, Controlled, Multicenter Study

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Nonanimal Sourced Hyaluronic Acid–Based Dermal Filler Using a Cohesive Polydensified Matrix Technology is Superior to Bovine Collagen in the Correction of Moderate to Severe Nasolabial Folds: Results from a 6-Month, Randomized, Blinded, Controlled, Multicenter Study

机译：使用内聚缩聚矩阵技术的非动物来源透明质酸真皮填充剂在中度至严重鼻唇沟褶皱的校正方面优于牛胶原蛋白：6个月，随机，盲目，对照，多中心研究的结果

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BACKGROUND Dermal fillers are used to augment wrinkles and folds, and a variety of hyaluronic acid (HA)-based products are available. The non-animal-sourced HA studied was cross-linked using a two-step process and employing cohesive polydensified matrix (CPM) technology. This HA gel (CPMHA) has variable density and viscosity zones for adaptation in the dermis.

机译：背景技术皮肤填充剂用于增加皱纹和褶皱，并且多种基于透明质酸（HA）的产品是可用的。研究的非动物来源的HA通过两步过程并使用内聚性增稠基质（CPM）技术进行交联。该HA凝胶（CPMHA）具有可变的密度和粘度区，可适应真皮。

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《Dermatologic Surgery》 |2010年第s1期|730-740|共11页
作者
RHODA S. NARINS MD; WILLIAM COLEMAN III MD; LISA DONOFRIO MD; DEREK H. JONES MD; COREY MAAS MD; GARY MONHEIT MD; MANDEEP KAUR MD; STARR L. GRUNDY BSC PHARM; ERIC J. PAPPERT MD; BHUSHAN HARDAS MD PHD;
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作者单位

Dermatology Surgery and Laser Center White Plains New York;

Health Science Center Tulane University New Orleans Louisiana;

Department of Dermatology School of Medicine Yale University New Haven Connecticut;

Skin Care and Laser Physicians Los Angeles California;

Maas Clinic San Francisco California;

Total Skin and Beauty Dermatology Center Birmingham Alabama;

Merz Pharmaceuticals LLC Irvine California;

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1. Nonanimal Sourced Hyaluronic Acid-Based Dermal Filler Using a Cohesive Polydensified Matrix Technology is Superior to Bovine Collagen in the Correction of Moderate to Severe Nasolabial Folds: Results from a 6-Month, Randomized, Blinded, Controlled, Multicenter Study [J] . Narins Rhoda S., Coleman William III, Donofrio Lisa, Dermatologic surgery . 2010,第1Suppla期

机译：使用内聚缩聚矩阵技术的非动物来源透明质酸基皮肤填充剂在中度至严重鼻唇沟褶皱的校正方面优于牛胶原蛋白：6个月，随机，盲目，对照，多中心研究的结果
2. Efficacy and safety of a new resilient hyaluronic acid dermal filler, in the correction of moderate‐to‐severe nasolabial folds: A 64‐week, prospective, multicenter, controlled, randomized, double‐blind and within‐subject study [J] . Kaufman‐Janette Joely, Taylor Susan C., Cox Sue Ellen, Journal of cosmetic dermatology . 2019,第5期

机译：新的弹性透明质酸皮肤填料的功效和安全性，在中度至严重的鼻涕折叠的校正中：64周，前瞻性，多中心，受控，随机，双盲和对象内研究
3. A comparison of the efficacy, safety, and longevity of two different hyaluronic acid dermal fillers in the treatment of severe nasolabial folds: a multicenter, prospective, randomized, controlled, single-blind, within-subject study [J] . Greg J Goodman, Phillip Bekhor, Michael Rich, Clinical, Cosmetic and Investigational Dermatology . 2011,第10期

机译：两种不同的透明质酸真皮填充剂治疗严重鼻唇沟的功效，安全性和寿命的比较：多中心，前瞻性，随机，对照，单盲，受试者内研究
4. A comparison of the efficacy safety and longevity of two different hyaluronic acid dermal fillers in the treatment of severe nasolabial folds: a multicenter prospective randomized controlled single-blind within-subject study [O] . Greg J Goodman, Phillip Bekhor, Michael Rich, 2011

机译：两种不同的透明质酸真皮填充剂治疗严重鼻唇沟的功效安全性和寿命的比较：多中心前瞻性随机对照单盲受试者内部研究
5. A comparison of the efficacy, safety, and longevity of two different hyaluronic acid dermal fillers in the treatment of severe nasolabial folds: a multicenter, prospective, randomized, controlled, single-blind, within-subject study [O] . Goodman, Greg J, Bekhor, Phillip, Rich, Michael, 2011

机译：两种不同的透明质酸真皮填充剂治疗严重鼻唇沟的功效，安全性和寿命的比较：一项多中心，前瞻性，随机，对照，单盲，受试者内部研究

Nonanimal Sourced Hyaluronic Acid–Based Dermal Filler Using a Cohesive Polydensified Matrix Technology is Superior to Bovine Collagen in the Correction of Moderate to Severe Nasolabial Folds: Results from a 6-Month, Randomized, Blinded, Controlled, Multicenter Study

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