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首页> 外文期刊>Biomedical Optics Express >Non-contact small animal fluorescence imaging system for simultaneous multi-directional angular-dependent data acquisition
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Non-contact small animal fluorescence imaging system for simultaneous multi-directional angular-dependent data acquisition

机译：非接触式小动物荧光成像系统，用于同时进行多向角度相关数据采集

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We present a novel non-contact small animal fluorescent molecular tomography (FMT) imaging system. At the heart of the system is a new mirror-based imaging head that was designed to provide 360-degree measurement data from an entire animal surface in one step. This imaging head consists of two conical mirrors, which considerably reduce multiple back reflections between the animal and mirror surfaces. These back reflections are common in existing mirror-based imaging heads and tend to degrade the quality of raw measurement data. In addition, the introduction of a novel ray-transfer operator allows for the inclusion of the angular dependent data in the image reconstruction process, which results in higher image resolution. We describe in detail the system design and implementation of the hardware components as well as the transport-theory-based image reconstruction algorithm. Using numerical simulations, measurements on a well-defined phantom and a live animal, we evaluate the system performance and show the advantages of our approach.
机译：我们提出了一种新型的非接触式小动物荧光分子断层扫描（FMT）成像系统。该系统的核心是一个新的基于镜像的成像头，该成像头旨在一步一步提供来自整个动物表面的360度测量数据。该成像头由两个锥形镜组成，可大大减少动物和镜表面之间的多次背反射。这些背反射在现有的基于镜像的成像头中很常见，并且会降低原始测量数据的质量。另外，新型射线传输算子的引入允许在图像重建过程中包括与角度相关的数据，这导致更高的图像分辨率。我们详细描述了硬件组件的系统设计和实现，以及基于传输理论的图像重建算法。通过使用数值模拟，对清晰定义的模型和活体动物的测量，我们评估了系统性能并显示了该方法的优势。

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