• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biomarker Research >Prognostic significance of miR-194 in endometrial cancer
【24h】

Prognostic significance of miR-194 in endometrial cancer

机译：miR-194在子宫内膜癌中的预后意义

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Endometrial cancer (EC) is the leading malignant tumor occurring in the female genital tract and some subtypes are highly invasive and metastatic. miRNAs are small non-coding RNAs that have a broad impact on cancer progression. In particular, miR-194 regulates epithelial to mesenchymal transition (EMT) by suppressing the expression of BMI-1 in EC. In this retrospective study, the clinical significance of miR-194 was investigated in archival EC specimens. We extracted total RNA from thirty-two EC samples and quantified the expression level of miR-194. We discovered that the expression level of miR-194 was significantly (P = 0.03) lower in type I EC patients with more advanced stage. In addition, patients with higher miR-194 levels have better prognosis than those with lower miR-194 levels (P = 0.0067; Cut-off value of miR-194 = 0.3). These results indicate that miR-194 has potential to serve as prognostic biomarker for EC patients.
机译：子宫内膜癌（EC）是女性生殖道中最主要的恶性肿瘤，某些亚型具有高度浸润性和转移性。 miRNA是小的非编码RNA，对癌症的进展有广泛的影响。特别是，miR-194通过抑制EC中BMI-1的表达来调节上皮向间质转化（EMT）。在这项回顾性研究中，在档案EC标本中研究了miR-194的临床意义。我们从32个EC样品中提取了总RNA，并定量了miR-194的表达水平。我们发现，miR-194的表达水平在晚期I型EC患者中显着降低（P = 0.03）。此外，miR-194水平较高的患者比miR-194水平较低的患者预后更好（P = 0.0067; miR-194的临界值= 0.3）。这些结果表明，miR-194有潜力作为EC患者的预后生物标志物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号