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首页> 外文期刊>Biomarkers and genomic medicine. >Effects of combined supplementation of vitamins C and E on the oxidative modification of low-density lipoprotein, soluble form of CD36, soluble vascular cell adhesion molecule-1, and nitriteitrate oxide levels in idiopathic nephrotic syndrome
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Effects of combined supplementation of vitamins C and E on the oxidative modification of low-density lipoprotein, soluble form of CD36, soluble vascular cell adhesion molecule-1, and nitriteitrate oxide levels in idiopathic nephrotic syndrome

机译：维生素C和E的联合添加对特发性肾病综合征低密度脂蛋白，可溶性CD36，可溶性血管细胞粘附分子1和亚硝酸盐/硝酸盐含量的氧化修饰的影响

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This study aimed to investigate whether a combined supplementation of vitamins C and E was able to modify the oxidized low-density lipoprotein (ox-LDL), soluble form of CD36 (sCD36), soluble vascular cell adhesion molecule-1 (sVCAM-1), and nitriteitrate oxide (NO"x) levels in pediatric nephrotic syndrome (NS) cases. The study included 36 children with NS. The patients were randomly allocated to either the treatment group or the placebo group (18 children each). The treatment group received a combined supplementation of vitamins C and E. The serum levels of ox-LDL, sCD36, and sVCAM-1 were assayed by enzyme-linked immunosorbent assay. The serum levels of NO"x were assayed by colorimetric assay. Results showed that the levels of ox-LDL, sVCAM-1, and NO"x were decreased after treatment with a combined supplementation of vitamins C and E, but there was no statistical difference (p > 0.05). After treatment, there was an increase in the level of sCD36 in both groups, although this was not significantly different (p > 0.05). The level of ox-LDL was significantly lower in the remission-idiopathic NS (remission-INS) group compared with the nonremission-INS group (p < 0.05). The levels of ox-LDL and sVCAM-1 were significantly lower in the remission-treated group than in the nonremission-treated group (p < 0.05). In conclusion, the combined supplementation of vitamins C and E cannot modify the ox-LDL, sCD36, sVCAM-1, and NO"x levels in children with INS. In remission cases, the combined supplementation of vitamins C and E reduces the ox-LDL and sVCAM-1 levels.
机译：这项研究旨在研究维生素C和E的组合补充是否能够修饰氧化型低密度脂蛋白（ox-LDL），可溶性形式的CD36（sCD36），可溶性血管细胞粘附分子1（sVCAM-1）小儿肾病综合征（NS）病例中的亚硝酸盐/亚硝酸盐/一氧化氮（NO“ x）水平的研究。该研究纳入了36例NS患儿，将患者随机分配至治疗组或安慰剂组（每例18例患儿）。治疗组接受维生素C和E的联合补充。通过酶联免疫吸附法测定ox-LDL，sCD36和sVCAM-1的血清水平，通过比色法测定NO“ x的血清水平。结果显示，在联合添加维生素C和E后，ox-LDL，sVCAM-1和NO“ x的含量降低，但无统计学差异（p> 0.05）。两组中sCD36水平均升高，但差异无统计学意义（p> 0.05）。缓解特发性NS（缓解-INS）组的ox-LDL水平显着低于非缓解-INS组（p <0.05）。缓解治疗组的ox-LDL和sVCAM-1水平显着低于非缓解治疗组（p <0.05）。结论是，维生素C和E不能同时补充修改INS儿童的ox-LDL，sCD36，sVCAM-1和NO“ x水平。在缓解的情况下，维生素C和E的联合补充会降低ox-LDL和sVCAM-1的水平。

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