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Hyper-Crosslinked Carbohydrate Polymer for Repair of Critical-Sized Bone Defects

机译：超交联碳水化合物聚合物，可修复临界骨缺损

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This study evaluated the safety and efficacy of a novel hyper-crosslinked carbohydrate polymer (HCCP) for the repair of critical-sized bone defects in comparison to two alternative treatments: autologous bone and poly(lactide-co-glycolide) with hyaluronic acid (PLGA/HA). Bilateral critical-sized defects were created in the lateral femoral condyles of skeletally mature New Zealand White rabbits, and they were subsequently implanted with HCCP, PLGA/HA, or autologous bone in a randomized manner. Clinical and behavioral observations were made daily, and radiological and histopathological evaluations were performed at 4, 10, and 16 weeks postimplantation. Defects implanted with HCCP showed progressive bone regeneration and bridging of the defect without adverse histological events. No signs of infection or inflammation associated with the implant material were observed in all animals that received HCCP implantation. A radiographic assessment performed at 16 weeks post-implantation showed significantly higher bone density and volume in defects implanted with HCCP compared to PLGA/HA. No statistically significant difference was observed in bone density and volume between HCCP and autologous bone. These findings demonstrate that HCCP is biocompatible, osteoconductive, and capable of promoting bone regeneration in vivo ; therefore, it is suitable for both tissue engineering and the repair of critical-sized bone defects.
机译：这项研究评估了与两种替代疗法：自体骨和透明质酸（PLGA）聚丙交酯-乙交酯共聚物相比，新型超交联碳水化合物聚合物（HCCP）修复临界大小骨缺损的安全性和有效性。 /哈）。在骨骼成熟的新西兰白兔的外侧股骨con中产生了双侧临界大小的缺损，随后将它们随机植入HCCP，PLGA / HA或自体骨。每天进行临床和行为观察，并在植入后第4、10和16周进行放射学和组织病理学评估。植入HCCP的缺损显示出渐进的骨再生和缺损桥接，而无不良组织学事件。在接受HCCP植入的所有动物中均未观察到与植入物相关的感染或炎症迹象。植入后16周进行的影像学评估显示，与PLGA / HA相比，HCCP植入的缺损的骨密度和骨量明显更高。 HCCP和自体骨之间在骨密度和体积上没有观察到统计学上的显着差异。这些发现表明，HCCP具有生物相容性，骨传导性，并能够在体内促进骨再生。因此，它既适合组织工程，也适合修复关键尺寸的骨缺损。

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