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首页> 外文期刊>BioPsychoSocial Medicine >The effectiveness of the Uchida-Kraepelin test for psychological stress: an analysis of plasma and salivary stress substances
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The effectiveness of the Uchida-Kraepelin test for psychological stress: an analysis of plasma and salivary stress substances

机译：Uchida-Kraepelin测试对心理压力的有效性：血浆和唾液应激物质的分析

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Background The hypothalamic-pituitary-adrenocortical (HPA) axis and sympathetic adrenomedullary (SAM) system are the major stress-response pathways. Plasma adrenocorticotropic hormone (ACTH) represents HPA axis activity, while plasma catecholamines are used as markers of the SAM system. Salivary alpha amylase (AA), chromogranin A (CgA), and immunoglobulin A (IgA) are candidate markers of stress activation, although their role has not been established. The Uchida-Kraepelin (U-K) test is a questionnaire that requires intense concentration and effort, and has been used as a tool to induce mental stress. However, it is not clear whether or not the test is effective as a psychological/mental stressor. Methods In this study, normal young women took the U-K test and serial measurements of plasma ACTH and catecholamines (dopamine, noradrenaline, and adrenaline) (n = 10), as well as salivary AA, CgA, and IgA (n = 16) before, during and after the test. Results We found no changes in any of these parameters at any time point during or after the U-K test. Conclusion Our findings indicate that the U-K test is not a suitable for measuring the psychological/mental stress of young women because the plasma data showed that it did not affect the HPA axis and SAM system. The U-K test should be employed carefully as a psychological/mental stressor due to insufficient scientific evidence of its effectiveness. In addition, salivary AA, CgA, and IgA should not simply be compared with previous reports, because the mechanism of secretion and normal range of each salivary parameter remain unknown. Salivary AA, CgA, and IgA may not be suitable candidate markers of psychological/mental stress.
机译：背景下丘脑-垂体-肾上腺皮质（HPA）轴和交感性肾上腺髓质（SAM）系统是主要的应激反应途径。血浆促肾上腺皮质激素（ACTH）代表HPA轴活性，而血浆儿茶酚胺被用作SAM系统的标志物。唾液α淀粉酶（AA），嗜铬粒蛋白A（CgA）和免疫球蛋白A（IgA）是应激激活的候选标记，尽管它们的作用尚未确定。 Uchida-Kraepelin（U-K）测试是一种需要高度集中精力的工作问卷，已被用作诱发精神压力的工具。但是，尚不清楚该测试作为心理/心理压力源是否有效。方法在这项研究中，正常的年轻女性在接受英国测试并连续测量血浆ACTH和儿茶酚胺（多巴胺，去甲肾上腺素和肾上腺素）（n = 10）以及唾液AA，CgA和IgA（n = 16）之前， ，测试期间和之后。结果我们在U​​-K测试期间或之后的任何时间都没有发现任何这些参数的变化。结论我们的发现表明，U-K测试不适用于测量年轻女性的心理/心理压力，因为血浆数据显示它不影响HPA轴和SAM系统。由于其有效性的科学证据不足，因此应谨慎地将U-K考试用作心理/心理压力源。此外，唾液AA，CgA和IgA不应简单地与以前的报道进行比较，因为每个唾液参数的分泌机制和正常范围仍然未知。唾液AA，CgA和IgA可能不是心理/心理压力的合适候选标记。

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