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首页> 外文期刊>BioPsychoSocial Medicine >Plasma intact fibroblast growth factor 23 levels in women with bulimia nervosa: A cross-sectional pilot study
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Plasma intact fibroblast growth factor 23 levels in women with bulimia nervosa: A cross-sectional pilot study

机译：神经性贪食症患者的血浆完整成纤维细胞生长因子23水平：一项横断面先导研究

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Fibroblast growth factor (FGF) 23, a circulating 26-kDa peptide produced by osteogenic cells, is a novel phosphaturic factor. In our previous study, binge-eating/purging type anorexia nervosa (AN-BP) patients had elevated plasma intact FGF23 (iFGF23) levels, while restricting type (AN-R) patients had plasma iFGF23 levels similar to healthy controls. Although bulimia nervosa (BN) patients as well as some patients with AN-BP regularly engage in binge eating, there have been no studies regarding plasma iFGF23 levels in BN patients. Therefore, this study was performed to determine plasma iFGF23 concentrations in BN patients and healthy controls. The study population consisted of 13 female BN patients and 11 healthy female controls. Blood samples were collected from all subjects after overnight fasting. Plasma iFGF23 was measured using an ELISA kit in a cross-sectional manner. The two-tailed Mann-Whitney U-test was used to assess differences between BN patients and healthy controls. In addition, BN patients were divided into two groups based on questionnaire-reported binge eating frequency immediately prior to participation in this study: high frequency of binge eating (once a week or more; HF group; n = 8) and low frequency of binge eating (less than once a week; LF group; n = 5). Two-tailed Mann-Whitney U-test with Bonferroni's correction was performed after the Kruskal-Wallis test to assess differences between HF group, LF group, and healthy controls. Median (quartiles) plasma iFGF23 levels were greater in BN patients (35.5 [14.8-65.0] pg/ml) than in controls (3.8 [not detected-5.3] pg/ml; p = 0.002). In addition, median (quartiles) plasma iFGF23 levels were greater in the HF group (62.3 [44.4-73.4] pg/ml) than in controls (p
机译：成纤维细胞生长因子（FGF）23是成骨细胞产生的26 kDa循环肽，是一种新型的磷酸化因子。在我们先前的研究中，暴食/清除型神经性厌食症（AN-BP）患者血浆完整FGF23（iFGF23）水平升高，而限制性饮食（AN-R）型患者血浆iFGF23水平与健康对照组相似。尽管神经性贪食症（BN）患者以及一些患有AN-BP的患者定期进行暴饮暴食，但尚无关于BN患者血浆iFGF23水平的研究。因此，进行这项研究以确定BN患者和健康对照者血浆iFGF23的浓度。研究人群包括13名女性BN患者和11名健康女性对照。过夜禁食后从所有受试者中采集血液样本。使用ELISA试剂盒以横截面方式测量血浆iFGF23。两尾Mann-Whitney U检验用于评估BN患者和健康对照之间的差异。此外，根据参加调查前的问卷报告的暴饮暴食频率，BN患者分为两组：暴饮暴食的频率较高（每周一次或多次; HF组; n = 8）和暴饮暴食的频率较低进食（每周少于一次; LF组; n = 5）。在Kruskal-Wallis检验后，进行Bonferroni校正的两尾Mann-Whitney U检验，以评估HF组，LF组和健康对照组之间的差异。 BN患者的血浆中（四分位数）血浆iFGF23水平（35.5 [14.8-65.0] pg / ml）高于对照组（3.8 [未检出-5.3] pg / ml; p = 0.002）。此外，HF组的血浆iFGF23中位数（四分位数）高于对照组（62.3 [44.4-73.4] pg / ml）（p

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