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首页> 外文期刊>BioResearch open access. >Bioactive Interlinked Extracellular Matrix–Like Silicon Nano-Network Fabricated by Femtosecond Laser Synthesis
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Bioactive Interlinked Extracellular Matrix–Like Silicon Nano-Network Fabricated by Femtosecond Laser Synthesis

机译：飞秒激光合成制备的生物活性互连细胞外基质-像硅纳米网络。

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Nanostructured silicon has proven to be a promising candidate in tissue engineering. However, recent research on fabrication of silicon scaffolds has been limited to expensive, complex, and time-consuming lithographic techniques that require the addition of caustic chemicals. Moreover, these techniques generate structures that do not truly mimic the extracellular matrix (ECM). Therefore, we introduce a novel, interlinked, silicon nano-network fabricated by MHz ultrafast laser synthesis. We demonstrate that ultrafast laser synthesis is simple, rapid, free of any chemical additions, and can be carried out under ambient conditions. Variation in laser parameters resulted in an alteration in the pore size and density of the silicon fibrous network. Microscopic analysis revealed a highly charged silicon network with elevated adhesion forces. In vitro bioactivity tests indicate the precipitation of bone-like apatite in just 3 days. Cell proliferation studies on the silicon nano-network present a 300% increase in comparison to its bulk counterpart. Scanning electron microscopy analysis shows healthy migration and attachment of cells on the silicon nano-network. This study points to a correlation between elevated cell proliferation and the ECM-like structure of the silicon nano-network. This ECM-like silicon nano-network suggests significant potential not only in tissue engineering and regeneration but also in other biomedical applications such as biosensor detection.
机译：纳米结构的硅已被证明是组织工程中有希望的候选者。但是，最近对硅支架制造的研究仅限于昂贵，复杂且耗时的光刻技术，这些技术需要添加腐蚀性的化学物质。而且，这些技术产生的结构不能真正模仿细胞外基质（ECM）。因此，我们介绍了一种通过MHz超快激光合成技术制造的新颖的，相互连接的硅纳米网络。我们证明了超快激光合成简单，快速，没有任何化学添加，并且可以在环境条件下进行。激光参数的变化导致硅纤维网络的孔径和密度发生变化。显微分析表明，带电力高的硅网络具有更高的粘附力。体外生物活性测试表明，仅3天即可沉淀出骨状磷灰石。与硅纳米网络上的细胞增殖研究相比，硅纳米网络上的细胞增殖研究显示增加了300％。扫描电子显微镜分析显示硅纳米网络上细胞的健康迁移和附着。这项研究指出了细胞增殖的增加与硅纳米网络的ECM样结构之间的相关性。这种类似于ECM的硅纳米网络不仅在组织工程和再生中，而且在其他生物医学应用（例如生物传感器检测）中都具有巨大的潜力。

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