...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Bioscience Reports >Decreased brown adipose tissue thermogenic activity following a reduction in brain serotonin by intraventricular p-chlorophenylalanine
【24h】

Decreased brown adipose tissue thermogenic activity following a reduction in brain serotonin by intraventricular p-chlorophenylalanine

机译：脑室内对氯苯丙氨酸降低脑内5-羟色胺后，棕色脂肪组织的产热活性降低

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The effects of reducing brain serotonin (5-HT) levels by means of intracerebral-ventricular injections of the tryptophan antagonist p-chlorophenylalanine (PCPA) were investigated in male rats. Six days after the operation, PCPA-treated rats, either fed ad libitum or pair-fed to the food intake of control rats, showed decreased thermogenic activity and capacity in their interscapular brown adipose tissue (BAT) and also increased fat storage in their white adipose tissue (WAT). These results indicate that serotonergic synapses might play a regulatory role in the sympathetic control of BAT thermogenesis and in the rate of WAT deposition (by an as yet unidentified mechanism), in addition to their well established role in controlling food intake.
机译：研究了通过脑室内注射色氨酸拮抗剂对氯苯丙氨酸（PCPA）降低大脑5-羟色胺（5-HT）水平的作用。手术六天后，以PCPA处理的大鼠随意喂食或成对喂食对照大鼠的食物，其肩inter间褐色脂肪组织（BAT）的生热活性和能力降低，并且其白色脂肪的存储量增加脂肪组织（WAT）。这些结果表明，血清素能突触除了在控制食物摄入方面已确立的作用外，还可能在BAT生热的交感神经控制和WAT沉积速率中发挥调节作用（目前尚不清楚）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号