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Effect of bilateral adrenalectomy on VIP receptor/effector system in rat intestinal epithelial cells

机译:双侧肾上腺切除术对大鼠肠上皮细胞VIP受体/效应系统的影响

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The number of vasoactive intestinal peptide (VIP) receptors and the efficiency of VIP in the stimulation of cyclic AMP accumulation in rat jejunal epithelial cells increased after bilateral adrenalectomy. However, this condition increased neither receptor affinity nor VIP potency. In addition, jejunal VIP levels followed a parallel increase. These changes reversed to control conditions after glucocorticoid replacement with dexamethasone indicating that adrenalectomy modifies the intestinal VIP receptor/effector system and suggest a relationship between corticosteroids and VIP in the functions of intestinal epithelium.
机译:双侧肾上腺切除术后,血管活性肠肽(VIP)受体的数量和VIP刺激大鼠空肠上皮细胞中环AMP积累的效率增加。但是,这种情况不会增加受体亲和力或VIP效力。此外,空肠VIP水平也随之上升。在地塞米松替代糖皮质激素后,这些变化与对照条件相反,表明肾上腺切除术改变了肠道VIP受体/效应系统,并暗示了皮质类固醇和VIP在肠道上皮功能中的关系。

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