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Modularity of osteoclast behaviour and “mode-specific” inhibition of osteoclast function

机译：破骨细胞行为的模块化和破骨细胞功能的“模式特异性”抑制

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This study is part of an attempt to understand the role of specific cellular activities in the bone resorptive process. Experiments were performed whereby known pharmacological agents were used to inhibit individual modes of osteoclastic activity, such as motility and secretion. The effects of such treatments on bone resorption were assessed by quantitative scanning electron microscopy. The compounds included colchicine, which was used to inhibit osteoclast motility; molybdate ions which were used to selectively inhibit the catalytic activity of secreted acid phosphatase, and omeprazole which was employed to inhibit the secretion of hydrogen ions. All compounds inhibited osteoclastic bone resorption, but singularly affected defined modes of activity. These findings suggest that each mode of osteoclastic activity is essential for the bone resorptive process, and that “mode-specific” inhibition may provide a means whereby excessive activity of the osteoclast can be regulated in disease.
机译：这项研究是了解特定细胞活动在骨吸收过程中的作用的尝试的一部分。进行了实验，其中使用了已知的药物来抑制破骨细胞活性的各个模式，例如运动性和分泌。通过定量扫描电子显微镜评估这种治疗对骨吸收的作用。这些化合物包括秋水仙碱，该水用于抑制破骨细胞的运动。用来选择性抑制分泌的酸性磷酸酶催化活性的钼酸根离子和用来抑制氢离子分泌的奥美拉唑。所有化合物均能抑制破骨细胞的骨吸收，但会单独影响确定的活动模式。这些发现表明，破骨细胞活性的每种模式对于骨吸收过程都是必不可少的，并且“模式特异性”抑制作用可能提供一种手段，从而可以在疾病中调节破骨细胞的过度活性。

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