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Somatostatin promotes accumulation of phospholipids in regenerating liver tissue of rats

机译:生长抑素促进大鼠再生肝组织中磷脂的积累

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Effects of somatostatin (SOM) on tissue contents of proteins, total lipids and phospholipids were investigated in regenerating and intact liver tissue of Y-59 rats. Whereas SOM inhibited protein accumulation in regenerating liver, the hormone evoked and increase in total lipids, and specially in phosphatidylcholine, phosphatidylethnolamine, phosphatidylserine (PS) and phosphatidylinositol (PI). Since the same effects were not seen when intact liver was analyzed, it is assumed that SOM acts primarily on tissue stimulated to rapid growth. The increase of PS+PI fractions indicates a specific effect of SOM on the metabolism of phosphatidylinositides. Such an effect might result from the interference of the hormone with the action of growth factors that accelerate phosphatidylinositol breakdown.
机译:研究了生长抑素(SOM)对Y-59大鼠再生和完整肝组织中蛋白质,总脂质和磷脂组织含量的影响。尽管SOM抑制了再生肝中蛋白质的积累,但荷尔蒙被诱发并增加了总脂质,特别是磷脂酰胆碱,磷脂酰羟胺,磷脂酰丝氨酸(PS)和磷脂酰肌醇(PI)中的激素。由于分析完整肝时未观察到相同的效果,因此可以假设SOM主要作用于刺激快速生长的组织。 PS + PI分数的增加表明SOM对磷脂酰肌醇的代谢具有特定作用。这种作用可能是由于激素干扰加速磷脂酰肌醇分解的生长因子的作用所致。

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