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首页> 外文期刊>BioPsychoSocial Medicine >Absence of change in the gray matter volume of patients with ulcerative colitis in remission: a voxel based morphometry study
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Absence of change in the gray matter volume of patients with ulcerative colitis in remission: a voxel based morphometry study

机译：缓解性溃疡性结肠炎患者灰质体积的变化：基于体素的形态学研究

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Background Recent neuroimaging studies have investigated the brain involvement in patients with Crohn's disease (CD) and Ulcerative Colitis (UC). Functional studies found abnormalities in cognitive and emotional functions in CD and UC, while a voxel based morphometry (VBM) study found morphological changes in CD. We conducted a VBM study to compare the gray matter (GM) volume of UC patients and controls. Methods Eighteen UC patients in remission and eighteen healthy controls underwent structural MRI. VBM is a fully automated technique allowing identification of regional differences in the amount of GM, which enables an objective analysis of the whole brain. VBM was used for comparisons between patients and controls. Results UC patients were all in remission and had a mild clinical course. There were no differences between patients and controls in GM volume. Conclusion The brain morphology of patients with UC in remission is similar to controls. The lack of GM abnormalities in UC patients might reflect the mild clinical course of the inflammatory bowel disorder. Further research involving patients with different degrees of disease severity or during flares could shed more light on potential brain structural changes in UC.
机译：背景技术最近的神经影像学研究已经调查了克罗恩病（CD）和溃疡性结肠炎（UC）患者的大脑受累情况。功能研究发现了CD和UC的认知和情绪功能异常，而基于体素的形态计量学（VBM）研究发现了CD的形态变化。我们进行了一项VBM研究，比较了UC患者和对照组的灰质（GM）量。方法对18例缓解期的UC患者和18例健康对照者进行结构MRI检查。 VBM是一种全自动技术，可以识别GM量的区域差异，从而可以对整个大脑进行客观分析。 VBM用于患者和对照之间的比较。结果UC患者均已缓解，临床病程较轻。患者和对照组的GM量无差异。结论缓解期UC患者的脑形态与对照组相似。 UC患者缺乏GM异常可能反映了炎症性肠病的轻度临床过程。进一步研究涉及不同程度的疾病严重程度或发作期间的患者，可能会进一步揭示UC潜在的脑结构变化。

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