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首页> 外文期刊>BMC Complementary and Alternative Medicine >Samsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice
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Samsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice

机译：Samsoeum水提取物通过调节Th1 / Th2细胞因子和降低哮喘小鼠iNOS表达来减轻过敏性气道炎症

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Background Samsoeum has long been used in Korea and other Asian countries as a traditional medicine to treat various diseases. In the present study, we investigated the antiasthma effect of the herbal medicine Samsoeum water extract (SSEW) using an in vivo ovalbumin (OVA)-induced asthmatic model. Methods Female BALB/c mice were sensitized by an intraperitoneal injection of OVA and subsequently challenged with nebulized OVA. We investigated the number of inflammatory cells, the production of Th1/Th2 cytokines and chemokine in bronchoalveolar lavage fluid (BALF), histological changes in lung tissue, the infiltration of inflammatory cells and hyperplasia of goblet cells in lung tissue, the levels of immunoglobulin E (IgE) in BALF and plasma, and the expression of inducible nitric oxide synthase (iNOS) in lung tissue. Results Our findings indicated that SSEW decreased the accumulation of inflammatory cells (particularly, eosinophil and neutrophil) and regulated the balance in the production of Th1/Th2 cytokines and chemokine in BALF. Moreover, SSEW suppressed the level of IgE in BALF and plasma, and inhibited the infiltration of inflammatory cells, hyperplasia of goblet cells, and the expression of iNOS in lung tissue. Conclusions Collectively, these results suggest that, because of its anti-inflammatory and antiasthma properties, SSEW may be useful in reducing airway inflammation in the treatment of allergic asthma.
机译：背景技术萨姆长久以来一直在韩国和其他亚洲国家用作治疗各种疾病的传统药物。在本研究中，我们使用体内卵清蛋白（OVA）诱导的哮喘模型研究了草药Samsoeum水提取物（SSEW）的抗哮喘作用。方法通过腹腔注射OVA致敏雌性BALB / c小鼠，然后用雾化的OVA攻击。我们调查了炎症细胞的数量，支气管肺泡灌洗液（BALF）中Th1 / Th2细胞因子和趋化因子的产生，肺组织的组织学变化，肺组织中炎性细胞的浸润和杯状细胞的增生，免疫球蛋白E的水平（IgE）在BALF和血浆中的表达，以及诱导型一氧化氮合酶（iNOS）在肺组织中的表达。结果我们的发现表明SSEW减少了BALF中炎性细胞（特别是嗜酸性粒细胞和嗜中性粒细胞）的积累，并调节了Th1 / Th2细胞因子和趋化因子产生的平衡。此外，SSEW抑制了BALF和血浆中IgE的水平，并抑制了炎症细胞的浸润，杯状细胞的增生以及iNOS在肺组织中的表达。结论综上所述，这些结果表明，由于SSEW具有抗炎和抗哮喘的特性，因此在减轻过敏性哮喘的气道炎症中可能有用。

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