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首页> 外文期刊>Bangladesh Pharmaceutical Journal >Evaluation of Antibacterial, Antifunfgal and Cytotoxic Potentials of Crude Metabolite of ANAM-39, a Marine Bacterium Isolated from Sundarbans, Bangladesh
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Evaluation of Antibacterial, Antifunfgal and Cytotoxic Potentials of Crude Metabolite of ANAM-39, a Marine Bacterium Isolated from Sundarbans, Bangladesh

机译：从孟加拉国桑达班斯分离出的海洋细菌ANAM-39粗代谢产物的抗菌，抗真菌和细胞毒性潜力评估

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The present study was undertaken to screen the antimicrobial, antifungal and cytotoxic potentials of crude metabolite of a marine bacterium isolated from a soil sample collected from Sundarbans, Bangladesh. Primary and secondary screenings for antimicrobial activity were conducted by cross streak and agar well diffusion method, respectively. The antifungal potency of the crude extract was also tested by agar well-diffusion method. The brine shrimp lethality test was conducted to determine the cytotoxic nature of crude metabolites, which showed that the degree of lethality of metabolite was directly proportional to the concentration (LC50 30.19 μg/ml). Further studies are needed to isolate and characterize the active principles present in the crude metabolite and determine their biological activity. The results of this investigation suggested that the soils of Sundarbans are rich sources of microorganisms with potent biological activities and systematic screening programs need to be conducted to explore the presence of pharmacologically active marine bacterial metabolites.Bangladesh Pharmaceutical Journal 18(2): 103-109, 2015
机译：进行本研究以筛选从从孟加拉国桑达尔班斯收集的土壤样品中分离出的海洋细菌粗代谢产物的抗微生物，抗真菌和细胞毒性潜力。通过交叉条纹和琼脂井扩散法分别进行了一次和二次抗菌活性筛选。还通过琼脂充分扩散方法测试粗提取物的抗真菌效力。进行了盐水虾致死性测试，以确定粗代谢产物的细胞毒性性质，这表明代谢产物的致死程度与浓度（LC50为30.19μg/ ml）成正比。需要进一步研究以分离和表征粗代谢物中存在的活性成分并确定其生物学活性。这项研究的结果表明，桑达班人的土壤是微生物的丰富来源，具有强大的生物活性，需要进行系统的筛选程序来探索具有药理活性的海洋细菌代谢产物的存在。孟加拉药学杂志18（2）：103-109 ，2015

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