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首页> 外文期刊>BMC Complementary and Alternative Medicine >Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial
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Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial

机译：空腹血糖受损或2型糖尿病患者中发酵红参的餐后降糖作用：一项随机，双盲，安慰剂对照的临床试验

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Background Red ginseng is prepared by steaming raw ginseng, a process believed to increase the pharmacological efficacy. Further bioconversion of red ginseng through fermentation is known to increase its intestinal absorption and bioactivity, and bioconversion diminishes the toxicity of red ginseng’s metabolite. This study was conducted to investigate the effects of daily supplementation with fermented red ginseng (FRG) on glycemic status in subjects with impaired fasting glucose or type 2 diabetes. Methods This study was a four-week long, randomized, double-blind, placebo-controlled trial. Forty-two subjects with impaired fasting glucose or type 2 diabetes were randomly allocated to two groups assigned to consume either the placebo or fermented red ginseng (FRG) three times per day for four weeks. Fasting and postprandial glucose profiles during meal tolerance tests were assessed before and after the intervention. Results FRG supplementation led to a significant reduction in postprandial glucose levels and led to an increase in postprandial insulin levels compared to the placebo group. There was a consistently significant improvement in the glucose area under the curve (AUC) in the FRG group. However, fasting glucose, insulin, and lipid profiles were not different from the placebo group. Conclusion Daily supplementation with FRG lowered postprandial glucose levels in subjects with impaired fasting glucose or type 2 diabetes. Trial registration ClinicalTrials.gov: NCT01826409
机译：背景红参是通过蒸生人参制备的，据信该工艺可提高药理功效。红参通过发酵进一步生物转化可增加其肠道吸收和生物活性，生物转化可减少红参代谢产物的毒性。这项研究旨在研究每日补充发酵红参（FRG）对空腹血糖受损或2型糖尿病患者血糖状况的影响。方法该研究是一项为期四周的随机，双盲，安慰剂对照试验。空腹血糖受损或2型糖尿病的42名受试者随机分为两组，分别服用安慰剂或发酵红参（FRG），每天三次，共4周。在干预之前和之后评估进餐耐受性测试期间的空腹和餐后血糖分布。结果与安慰剂组相比，补充FRG导致餐后血糖水平显着降低，并导致餐后胰岛素水平升高。 FRG组的曲线下葡萄糖面积（AUC）持续显着改善。但是，空腹血糖，胰岛素和血脂水平与安慰剂组无差异。结论每日补充FRG可降低空腹血糖受损或2型糖尿病患者的餐后血糖水平。试用注册ClinicalTrials.gov：NCT01826409

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