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首页> 外文期刊>BMC Ear, Nose and Throat Disorders >Isolation and antimicrobial drug susceptibility pattern of bacterial pathogens from pediatric patients with otitis media in selected health institutions, Addis Ababa, Ethiopia: a prospective cross-sectional study
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Isolation and antimicrobial drug susceptibility pattern of bacterial pathogens from pediatric patients with otitis media in selected health institutions, Addis Ababa, Ethiopia: a prospective cross-sectional study

机译：埃塞俄比亚亚的斯亚贝巴的部分医疗机构小儿中耳炎患者的细菌病原菌的分离和抗菌药物敏感性模式：前瞻性横断面研究

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摘要

Otitis media is inflammation of the middle ear and tympanic membrane, which often occurs after an acute upper respiratory tract infection. It is the most common episode of infection in children and the second most important cause of hearing loss affecting 1.23 billion people, thus ranked fifth global burden of disease with a higher incidence in sub-Saharan Africa. Thus, the aim of this study was to determine the isolation rate of bacterial pathogens from pediatric patients with otitis media. Institutional based cross-sectional study was conducted from January 2013–June 2014 in Addis Ababa among 210 pediatrics patients. Demographic, clinical and associated factors data was obtained in face to face interview with guardians/parents by 5 trained nurse data collectors using structured questionnaire. Middle ear drainage swab was collected following all aseptic procedures and transported to the microbiology laboratory. Culture and Antimicrobial sensitivity test were performed according to the standards. The data quality was assured by questionnaire translation, retranslation and pretesting. Reference strains were used as a positive and negative control for biochemical tests, and culture results were cross checked. Data was checked for completeness, consistency and then entered into Epi Info v3.5.1 and analyzed by SPSS v20. Data interpretation was made using graphs, tables, and result statements. A total of 196 middle ear drainage swab samples were analyzed from pediatric patients and of those 95 (48.5%) samples were positive for pathogenic organisms. The major isolate was S. aureus (15.8%) followed by P. aeruginosa (10.9%), Viridians streptococcus (9.9%), S. pneumoniae (8.9%) and S. pyogenes (7.9%). Upper respiratory tract infection history and living in the rural area have shown significant association with the isolation of pathogenic organism, (p-value?=?0.035) and (p-value?=?0.003) respectively. Most of the isolates show a high level of resistance to Trimethoprim-Sulfamethoxazole, Penicillin G, Ampicillin, Amoxicillin, and Chloramphenicol. S. aureus and P. aeruginosa are the most common pathogens that contribute to otitis media as well most of the isolates show a high level of resistance to commonly used drugs to treat otitis media. Therefore, culture and susceptibility testes have paramount importance for the better management of otitis media and drug-resistant infections.
机译：中耳炎是中耳和鼓膜的炎症，通常在急性上呼吸道感染后发生。它是儿童中最常见的感染事件，也是影响12.3亿人的听力损失的第二大最重要原因，因此在撒哈拉以南非洲地区，全球疾病负担排名第五，发病率更高。因此，本研究的目的是确定患儿中耳炎的细菌病原体的分离率。 2013年1月至2014年6月在亚的斯亚贝巴进行了基于机构的横断面研究，涉及210名儿科患者。通过结构化问卷，由5位训练有素的护士数据收集者在与监护人/父母的面对面访谈中获得了人口统计学，临床和相关因素数据。按照所有无菌程序收集中耳引流棉签，并运送到微生物学实验室。根据标准进行培养和抗菌敏感性测试。通过问卷翻译，重新翻译和预测试来确保数据质量。将参考菌株用作生化测试的阳性和阴性对照，并对培养结果进行交叉检查。检查数据的完整性和一致性，然后将其输入Epi Info v3.5.1并通过SPSS v20进行分析。数据解释使用图形，表格和结果语句进行。儿科患者共分析了196个中耳引流棉签样本，其中95个样本（48.5％）对病原体呈阳性。主要分离株是金黄色葡萄球菌（15.8％），其次是铜绿假单胞菌（10.9％），弧菌链球菌（9.9％），肺炎链球菌（8.9％）和化脓性链球菌（7.9％）。上呼吸道感染的历史和农村地区的生活状况与病原菌的分离显着相关，分别为（p值≤0.035）和（p值≤0.003）。大多数分离株对甲氧苄啶-磺胺甲基异恶唑，青霉素G，氨苄青霉素，阿莫西林和氯霉素具有很高的抗药性。金黄色葡萄球菌和铜绿假单胞菌是导致中耳炎的最常见病原体，大多数分离株对治疗中耳炎的常用药物表现出很高的抵抗力。因此，培养和敏感性睾丸对于更好地治疗中耳炎和耐药性感染至关重要。

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