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首页> 外文期刊>BMC Biotechnology >Isolation of nanomolar scFvs of non-human primate origin, cross-neutralizing botulinum neurotoxins A1 and A2 by targeting their heavy chain
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Isolation of nanomolar scFvs of non-human primate origin, cross-neutralizing botulinum neurotoxins A1 and A2 by targeting their heavy chain

机译：分离非人类灵长类动物来源的纳摩尔scFv，通过靶向其重链交叉中和肉毒杆菌神经毒素A1和A2

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Background Botulism is a naturally occurring disease, mainly caused by the ingestion of food contaminated by the botulinum neurotoxins (BoNTs). Botulinum neurotoxins are the most lethal. They are classified among the six major biological warfare agents by the Centers for Disease Control. BoNTs act on the cholinergic motoneurons, where they cleave proteins implicated in acetylcholine vesicle exocytosis. This exocytosis inhibition induces a flaccid paralysis progressively affecting all the muscles and generally engendering a respiratory distress. BoNTs are also utilized in medicine, mainly for the treatment of neuromuscular disorders, preventing large scale vaccination. Botulism specific treatment requires injections of antitoxins, usually of equine origin and thus poorly tolerated. Therefore, development of human or human-like neutralizing antibodies is of a major interest, and it is the subject of the European framework project called “AntiBotABE”.
机译：背景肉毒杆菌中毒是一种自然发生的疾病，主要是由于摄入被肉毒杆菌神经毒素（BoNT）污染的食物引起的。肉毒杆菌神经毒素是最致命的。他们被疾病控制中心归类为六种主要的生物战剂。 BoNT作用于胆碱能运动神经元，在那里它们裂解与乙酰胆碱囊泡胞吐有关的蛋白质。这种胞吐抑制作用引起松弛性麻痹，逐渐麻痹所有肌肉，并通常引起呼吸窘迫。 BoNT还用于医学中，主要用于治疗神经肌肉疾病，预防大规模疫苗接种。肉毒杆菌中毒治疗需要注射通常来自马的抗毒素，因此耐受性差。因此，开发人或类人中和抗体非常重要，这是欧洲框架项目“ AntiBotABE”的主题。

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