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首页> 外文期刊>Biotemas >Atividade antibacteriana do óleo essencial de Melaleuca alternifolia frente a isolados multirresistentes produtores de ESBL e KPC causadores de infec??es hospitalares
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Atividade antibacteriana do óleo essencial de Melaleuca alternifolia frente a isolados multirresistentes produtores de ESBL e KPC causadores de infec??es hospitalares

机译：白千层精油对产生医院感染的ESBL和KPC的多重耐药菌株的抗菌活性

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The production of β-lactamases by Gram-negative bacteria is the main form of antimicrobial resistance, especially broad-spectrum β-lactamases (ESBL) and carbapenemases (KPC). To control multiresistant microorganisms, secondary plant metabolites are being studied to develop new drugs. The essential oil of Melaleuca alternifolia (OTT) has antifungal, anti-inflammatory and antimicrobial effects, of which the latter is attributed mainly to terpenes present in its composition. This work aimed to determine the antimicrobial potential of OTT emulsions against ESBL- and KPC- producing, multiresistant isolates of Escherichia coli and Klebsiella pneumoniae isolates responsible for nosocomial infections. The antibacterial activity of the essential oil emulsions was determined by the minimum inhibitory concentration (MIC) using the following methods: tube macrodilution, spot-on-the-lawn, agar diffusion and disk diffusion. Concentrations that inhibited bacterial growth ranged from 0.25% to 1.5% for the different methodologies applied. The essential oil emulsions of Melaleuca alternifolia inhibited the growth of multiresistant bacteria, as observed for the tube macrodilution and spot-on-the-lawn methods. The ESBL-producing Escherichia coli proved to be the most sensitive strain to describe the antibacterial potential of the oil, which should be evaluated in future studies as a control agent.
机译：革兰氏阴性细菌产生β-内酰胺酶是抗药性的主要形式，尤其是广谱的β-内酰胺酶（ESBL）和碳青霉烯酶（KPC）。为了控制多抗微生物，正在研究植物次生代谢产物以开发新药。白千层（OTT）的精油具有抗真菌，抗炎和抗微生物作用，其中后者主要归因于其成分中存在的萜烯。这项工作旨在确定OTT乳液对产生ESBL和KPC的多耐药性大肠杆菌和负责医院感染的肺炎克雷伯菌的分离物具有抗微生物作用。使用以下方法通过最小抑菌浓度（MIC）确定香精油乳液的抗菌活性：试管大稀释，草坪上斑点，琼脂扩散和圆盘扩散。对于所应用的不同方法，抑制细菌生长的浓度范围为0.25％至1.5％。如试管宏观稀释法和草坪上斑点法所观察到的，互生白千层精油乳剂可抑制多重耐药菌的生长。事实证明，产ESBL的大肠杆菌是描述该油抗菌潜力的最敏感菌株，应在以后的研究中作为控制剂进行评估。

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