Generation and analysis of the improved human HAL9/10 antibody phage display libraries

Jonas Kügler; Sonja Wilke; Doris Meier; Florian Tomszak; André Frenzel; Thomas Schirrmann; Stefan Dübel; Henk Garritsen; Bj?rn Hock; Lars Toleikis; Mark Schütte; Michael Hust

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Generation and analysis of the improved human HAL9/10 antibody phage display libraries

机译：改进的人HAL9 / 10抗体噬菌体展示文库的生成和分析

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Background Antibody phage display is a proven key technology that allows the generation of human antibodies for diagnostics and therapy. From naive antibody gene libraries - in theory - antibodies against any target can be selected. Here we describe the design, construction and characterization of an optimized antibody phage display library.

机译：背景技术抗体噬菌体展示是一种经过验证的关键技术，可产生用于诊断和治疗的人抗体。从理论上可以从天然抗体基因库中选择针对任何靶标的抗体。在这里，我们描述了优化的抗体噬菌体展示文库的设计，构建和表征。

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《BMC Biotechnology》 |2015年第1期|共页
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Jonas Kügler; Sonja Wilke; Doris Meier; Florian Tomszak; André Frenzel; Thomas Schirrmann; Stefan Dübel; Henk Garritsen; Bj?rn Hock; Lars Toleikis; Mark Schütte; Michael Hust;
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中图分类生物工程学（生物技术）;
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2. Phage display as a tool to study human autoantibodies and autoantigens in systemic autoimmune disease. Selection of recombinant (auto)-antibodies specific for human autoantigens in rheumatic disease (RA, SLE, SSc) from human autoimmune-patient and immunized chicken derived phage display libraries [J] . J Raats, W Degen, S Litjens, Arthritis Research . 2001,第SupplaA期

机译：噬菌体展示可作为研究系统性自身免疫疾病中人类自身抗体和自身抗原的工具。从人类自身免疫患者和免疫鸡源噬菌体展示文库中选择风湿性疾病（RA，SLE，SSc）中针对人类自身抗原的重组（自身）抗体
3. Intravenous infusion of phage-displayed antibody library in human cancer patients: Enrichment and cancer-specificity of tumor-homing phage-antibodies [J] . ShuklaG.S., KragD.N., PeletskayaE.N., Cancer immunology, immunotherapy : . 2013,第8期

机译：静脉输注人类癌症患者的噬菌体展示抗体库：肿瘤归巢噬菌体抗体的富集和癌症特异性
4. Characterization of Human Antibody Light Chain-Displaying Phage Library [C] . Toshihide Asada, Satoshi Muraoka, Shuhei Hashiguchi Japanese peptide symposium . 2010

机译：人抗体轻链显示噬菌体文库的表征
5. Applications of phage-displayed antibody library for antibody discovery and engineering. [D] . Zhao, Qi. 2008

机译：噬菌体展示抗体库在抗体发现和工程设计中的应用。
6. Generation and analysis of the improved human HAL9/10 antibody phage display libraries [O] . Jonas Kügler, Sonja Wilke, Doris Meier, 2015

机译：改进的人HAL9 / 10抗体噬菌体展示文库的生成和分析
7. Generation and analysis of the improved human HAL9/10 antibody phage display libraries [O] . Jonas Kügler, Sonja Wilke, Doris Meier, 2015

机译：改进的人HAL9 / 10抗体噬菌体展示文库的生成和分析

Generation and analysis of the improved human HAL9/10 antibody phage display libraries

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