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首页> 外文期刊>BMC Cancer >The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study
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The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study

机译：短期禁食对乳腺癌和卵巢癌患者生活质量和化疗耐受性的影响：一项随机交叉试验研究

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This pilot trial aimed to study the feasibility and effects on quality of life (QOL) and well-being of short-term fasting (STF) during chemotherapy in patients with gynecological cancer. In an individually-randomized cross-over trial patients with gynecological cancer, 4 to 6 planned chemotherapy cycles were included. Thirty-four patients were randomized to STF in the first half of chemotherapies followed by normocaloric diet (group A;n?=?18) or vice versa (group B;n?=?16). Fasting started 36?h before and ended 24?h after chemotherapy (60?h-fasting period). QOL was assessed by the FACIT-measurement system. The chemotherapy-induced reduction of QOL was less than the Minimally Important Difference (MID; FACT-G?=?5) with STF but greater than the MID for non-fasted periods. The mean chemotherapy-induced deterioration of total FACIT-F was 10.4?±?5.3 for fasted and 27.0?±?6.3 for non-fasted cycles in group A and 14.1?±?5.6 for non-fasted and 11.0?±?5.6 for fasted cycles in group B. There were no serious adverse effects. STF during chemotherapy is well tolerated and appears to improve QOL and fatigue during chemotherapy. Larger studies should prove the effect of STF as an adjunct to chemotherapy. This trial was registered at clinicaltrials.gov: NCT01954836 .
机译：这项试验性试验旨在研究妇科癌症患者化疗期间的生活质量（QOL）和短期禁食（STF）健康的可行性和影响。在具有妇科癌症的个体随机交叉试验患者中，包括4至6个计划的化疗周期。三十四例患者在化疗的前半部分被随机分配至STF，随后接受高热量饮食（A组;n≥18），反之亦然（B组;n≥16）。空腹开始于化疗前36小时，结束于化疗后24小时（空腹60小时）。 QOL由FACIT测量系统评估。化疗引起的QOL降低小于STF的最小重要差异（MID;FACT-Gα=？5），但大于非禁食期的MID。 A组空腹化疗的平均化学诱导总FACIT-F恶化为10.4±±5.3，非空腹周期为27.0±±6.3，非空腹为14.1±±5.6，非空腹为11.0±±5.6。 B组禁食。无严重不良反应。化疗期间的STF耐受性良好，并且似乎可以改善化疗期间的QOL和疲劳。更大的研究应该证明STF作为化疗的辅助作用。该试验已在Clinicaltrials.gov上注册：NCT01954836。

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