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p53?￠????Guardian Angel and Archangel

机译：p53？￠ ????守护天使与大天使

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p53 is a master regulator of the cell cycle, capable of assessing the severity and the scope of damage to the cellular DNA, integrating the signals from the cell under stress and delivering the final decision about the destiny of the cell?￠????undertaking repair activities; entering replicative senescence; inducing cell death; resorting to translesion transactions or altering the metabolism or the expression pattern of the cell. Proper functioning of p53 and its related pathways is essential in multicellular eukaryotes, with failures in the DNA-binding and transactivation properties of p53 usually resulting in cancer. Recent research on some common polymorphic variants of p53 that exhibit differential properties in their ability to induce cell cycle arrest or apoptosis indicate that p53 is not only the ?￠????guardian angel?￠???? of the genome, as is commonly believed, keeping its integrity in check and disposing of damaged cells, but it is as well the ?￠????archangel?￠???? that is responsible for cutting down the lifespan of the organism by the mechanism of ageing. One function can hardly exist without the other, and it is very individual as to whether carriership of one polymorphic form or another would be beneficial in the particular case, considering the general status of the patient and the specificities of the pathogenesis of the disease or condition in question. Age of the patient seems to be a major determining factor, as the differential pattern in the properties of p53 seems to become more pronounced as age advances.
机译：p53是细胞周期的主要调控因子，能够评估细胞DNA的严重程度和破坏范围，整合来自细胞在压力下的信号，并做出有关细胞命运的最终决定。进行维修活动;进入复制性衰老;诱导细胞死亡;借助跨病变交易或改变细胞的新陈代谢或表达模式。 p53及其相关途径的正常功能在多细胞真核生物中至关重要，而p53的DNA结合和反式激活特性失败通常会导致癌症。对一些常见的p53多态性变体的最新研究表明，它们在诱导细胞周期停滞或凋亡的能力上具有差异性，这表明p53不仅是“守护天使”，而且是“守护天使”。正如人们普遍认为的那样，它可以保持其完整性以检查和处置受损细胞，但是它也可以保持基因组的完整性。通过衰老的机制减少了生物的寿命。一种功能几乎不可能没有另一种功能存在，并且考虑到患者的一般状况以及疾病或病症的发病机理的特殊性，在特定情况下，一种多态性形式或另一种多态性形式的携带是否有益将非常个体化。问题。患者的年龄似乎是一个主要的决定因素，因为随着年龄的增长，p53的特性差异模式似乎变得更加明显。

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