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首页> 外文期刊>BioTechnology: An Indian Journal >Interaction between Minodiaq and bovine hemoglobin: Fluorescence study
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Interaction between Minodiaq and bovine hemoglobin: Fluorescence study

机译：Minodiaq和牛血红蛋白之间的相互作用：荧光研究

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The interaction between Bovine Hemoglobin (BHb) and Minodiaq was investigated at different temperatures by fluorescence spectroscopy, as well as the effect of some metal ions (Mg2+, Zn2+, Cu2+, Mn2+, Ni2+, V5+, Mo6+, Cr6+) on the BHb-Minodiaq system. Results showed that Minodiaq could quench the intrinsic fluorescence of BHb, and the quenching mechanism was a dynamic quenching process. The hydrophobic force played an important role on the conjugation reaction between BHb and Minodiaq. Synchronous spectra and CD spectra revealed that the microenvironment and the conformation of BHb were changed during the binding reaction. Studies on the interaction between BHb and drug will facilitate interpretation of the drug???s metabolism and transporting process in the blood, and will help to explain the relationship between structures and functions of BHb.
机译：通过荧光光谱在不同温度下研究了牛血红蛋白（BHb）与Minodiaq之间的相互作用以及某些金属离子（Mg2 +，Zn2 +，Cu2 +，Mn2 +，Ni2 +，V5 +，Mo6 +，Cr6 +）对BHb-Minodiaq的影响系统。结果表明，Minodiaq可以猝灭BHb的固有荧光，猝灭机理是一个动态的猝灭过程。疏水力在BHb与Minodiaq之间的共轭反应中起重要作用。同步光谱和CD光谱表明，BHb的微环境和构象在结合反应过程中发生了变化。 BHb与药物之间相互作用的研究将有助于解释药物在血液中的代谢和运输过程，并有助于解释BHb的结构与功能之间的关系。

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