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首页> 外文期刊>BMC Cancer >Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer) human prostate
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Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer) human prostate

机译：IAP在前列腺癌进展中的作用：在正常和病理（良性增生，前列腺上皮内瘤变和癌症）人类前列腺中的免疫组织化学研究

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Background In this study was investigate IAPs in normal human prostate (NP), benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN) and prostatic carcinoma (PC), and their involvement in apoptosis/proliferation via NF-kB (TNF-α, IL-1) stimulation. Methods Immunohistochemical and Western blot analyses were performed in 10 samples of normal prostates, 35 samples of BPH, 27 samples diagnosis of PIN (with low-grade PIN or high-grade PIN) and 95 samples of PC (with low, medium or high Gleason grades). Results In NP, cytoplasm of epithelial cells were positive to c-IAP1/2 (80% of samples), c-IAP-2 (60%), ILP (20%), XIAP (20%); negative to NAIP and survivin. In BPH, epithelial cells were immunostained to c-IAP1/2 (57.57%), c-IAP-2 (57.57%), ILP (66.6%), NAIP (60.6%), XIAP (27.27%), survivin (9.1%). Whereas low-grade PIN showed intermediate results between NP and BPH; results in high-grade PIN were similar to those found in PC. In PC, epithelial cells were immunostained to c-IAP1/2, c-IAP-2, ILP, NAIP, XIAP (no Gleason variation) and survivin (increasing with Gleason). Conclusions IAPs could be involved in prostate disorder (BPH, PIN and PC) development since might be provoke inhibition of apoptosis and subsequently cell proliferation. At the same time, different transduction pathway such as IL-1/NIK/NF-kB or TNF/NF-kB (NIK or p38) also promotes proliferation. Inhibitions of IAPs, IL-1α and TNFα might be a possible target for PC treatment since IAPs are the proteins that inhibited apoptosis (favour proliferation) and IL-1α and TNFα would affect all the transduction pathway involucrate in the activation of transcription factors related to survival or proliferation (NF-kB, Elk-1 or ATF-2).
机译：背景技术在这项研究中，研究了正常人前列腺（NP），良性前列腺增生（BPH），前列腺上皮内瘤变（PIN）和前列腺癌（PC）中的IAP及其通过NF-kB（TNF-α）参与凋亡/增殖的情况。 ，IL-1）刺激。方法对10例正常前列腺，35例BPH，27例诊断为PIN（低级或高级PIN）和95例PC（低，中或高格里森）进行免疫组织化学和Western blot分析年级）。结果在NP中，上皮细胞的细胞质对c-IAP1 / 2（样品的80％），c-IAP-2（60％），ILP（20％），XIAP（20％）呈阳性。对NAIP和survivin呈阴性。在BPH中，上皮细胞被免疫染色至c-IAP1 / 2（57.57％），c-IAP-2（57.57％），ILP（66.6％），NAIP（60.6％），XIAP（27.27％），存活蛋白（9.1％） ）。低等级PIN在NP和BPH之间显示中间结果;高档PIN的结果与PC中的结果相似。在PC中，上皮细胞被免疫染色到c-IAP1 / 2，c-IAP-2，ILP，NAIP，XIAP（无Gleason变异）和survivin（Gleason增加）。结论IAPs可能与前列腺疾病（BPH，PIN和PC）有关，因为它可能引起细胞凋亡和随后的细胞增殖抑制。同时，不同的转导途径如IL-1 / NIK / NF-kB或TNF / NF-kB（NIK或p38）也促进增殖。 IAP，IL-1α和TNFα的抑制可能是PC治疗的靶标，因为IAP是抑制细胞凋亡（促进增殖）的蛋白，而IL-1α和TNFα会影响所有与转录相关的转录因子激活的转导途径。存活或增殖（NF-kB，Elk-1或ATF-2）。

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