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首页> 外文期刊>BMC Cardiovascular Disorders >Association between lowered endothelial function measured by peripheral arterial tonometry and cardio-metabolic risk factors – a cross-sectional study of Finnish municipal workers at risk of diabetes and cardiovascular disease
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Association between lowered endothelial function measured by peripheral arterial tonometry and cardio-metabolic risk factors – a cross-sectional study of Finnish municipal workers at risk of diabetes and cardiovascular disease

机译：通过外周动脉眼压测量法测得的内皮功能降低与心血管代谢危险因素之间的关联–面临糖尿病和心血管疾病风险的芬兰市政工作者的横断面研究

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Background The aim of this cross-sectional study was to determine the association between lowered endothelial function measured by peripheral arterial tonometry (PAT) and cardio-metabolic risk factors. The study population consisted of Finnish municipal workers who were at risk of diabetes or cardiovascular disease and who had expressed a need to change their health behaviour. Methods A total of 312 middle-aged municipal workers underwent a physical medical examination and anthropometry measurements. Levels of total cholesterol, HDL cholesterol, triglycerides, fasting glucose, glycated haemoglobin, and high sensitivity C-reactive protein were taken from the blood samples. PAT measured the increase in digital pulse volume amplitude during reactive hyperemia, and the index of endothelial function, F-RHI, was defined as the ratio of post-deflation amplitude to baseline amplitude. Results In the linear regression model, male sex was associated with lower F-RHI. In sex-adjusted linear regression models, each of the variables; waist circumference, fasting glucose, glycated hemoglobin, triglycerides, body fat percentage, body mass index, current smoking, and impaired fasting glucose or diabetes were separately associated with lower F-RHI, and HDL cholesterol and resting heart rate were associated with higher F-RHI. HDL cholesterol, sex, body mass index, and current smoking entered a stepwise multivariable regression model, in which HDL cholesterol was associated with higher F-RHI, and smoking, male sex and body mass index were associated with lower F-RHI. This model explains 28.3% of the variability in F-RHI. Conclusions F-RHI is associated with several cardio-metabolic risk factors; low level of HDL cholesterol, male sex, overweight and smoking being the most important predictors of a lowered endothelial function. A large part of variation in F-RHI remains accounted for by unknown factors.
机译：背景这项横断面研究的目的是确定通过外周动脉眼压测量法（PAT）测得的内皮功能降低与心血管代谢危险因素之间的关系。研究人群包括有患糖尿病或心血管疾病危险的芬兰市政工作者，他们表示需要改变其健康行为。方法对312名中年市政工人进行身体检查和人体测量。从血样中获取总胆固醇，高密度脂蛋白胆固醇，甘油三酸酯，空腹血糖，糖化血红蛋白和高敏感性C反应蛋白的水平。 PAT测量了反应性充血过程中数字脉冲体积振幅的增加，并且内皮功能指数F-RHI定义为放气后振幅与基线振幅之比。结果在线性回归模型中，男性与较低的F-RHI有关。在经过性别调整的线性回归模型中，每个变量都可以;腰围，空腹血糖，糖化血红蛋白，甘油三酸酯，体脂百分比，体重指数，当前吸烟以及空腹血糖受损或糖尿病分别与较低的F-RHI相关，而HDL胆固醇和静息心率与较高的F-R相关。 RHI。 HDL胆固醇，性别，体重指数和当前吸烟进入逐步多元回归模型，其中HDL胆固醇与较高的F-RHI相关，而吸烟，男性和体重指数与较低的F-RHI相关。该模型解释了F-RHI中28.3％的变异性。结论F-RHI与多种心脏代谢危险因素有关。低水平的HDL胆固醇，男性，超重和吸烟是内皮功能降低的最重要预测因素。 F-RHI的大部分变化仍由未知因素引起。

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