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首页> 外文期刊>BMC Medical Genomics >Differentially expressed proteins in positive versus negative HNSCC lymph nodes
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Differentially expressed proteins in positive versus negative HNSCC lymph nodes

机译：阳性和阴性HNSCC淋巴结中差异表达的蛋白质

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Lymph node metastasis is one of the most important prognostic factors in head and neck squamous cell carcinomas (HNSCCs) and critical for delineating their treatment. However, clinical and histological criteria for the diagnosis of nodal status remain limited. In the present study, we aimed to characterize the proteomic profile of lymph node metastasis from HNSCC patients. In the present study, we used one- and two-dimensional electrophoresis and mass spectrometry analysis to characterize the proteomic profile of lymph node metastasis from HNSCC. Comparison of metastatic and non-metastatic lymph nodes showed 52 differentially expressed proteins associated with neoplastic development and progression. The results reinforced the idea that tumors from different anatomical subsites have dissimilar behaviors, which may be influenced by micro-environmental factor including the lymphatic network. The expression pattern of heat shock proteins and glycolytic enzymes also suggested an effect of the lymph node environment in controlling tumor growth or in metabolic reprogramming of the metastatic cell. Our study, for the first time, provided direct evidence of annexin A1 overexpression in lymph node metastasis of head and neck cancer, adding information that may be useful for diagnosing aggressive disease. In brief, this study contributed to our understanding of the metastatic phenotype of HNSCC and provided potential targets for diagnostic in this group of carcinomas.
机译：淋巴结转移是头颈部鳞状细胞癌（HNSCC）的最重要的预后因素之一，对于描述其治疗方法至关重要。然而，用于诊断淋巴结状况的临床和组织学标准仍然有限。在本研究中，我们旨在表征HNSCC患者淋巴结转移的蛋白质组学特征。在本研究中，我们使用了一维和二维电泳和质谱分析来表征HNSCC淋巴结转移的蛋白质组学特征。转移性和非转移性淋巴结的比较显示52种差异表达的蛋白与肿瘤的发生和发展有关。结果强化了这样的想法，即来自不同解剖亚位点的肿瘤具有不同的行为，这可能受包括淋巴网络在内的微环境因素的影响。热休克蛋白和糖酵解酶的表达方式还表明淋巴结环境在控制肿瘤生长或转移细胞的代谢重编程中具有作用。我们的研究首次为头颈癌淋巴结转移中膜联蛋白A1的过表达提供了直接证据，并增加了可能对诊断侵袭性疾病有用的信息。简而言之，这项研究有助于我们了解HNSCC的转移表型，并为这一组癌症的诊断提供了潜在的靶标。

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