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Effect of ethanol-treated mid-peripheral epithelium on corneal wound healing in rabbits

机译：乙醇处理的中周上皮对兔角膜伤口愈合的影响

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Background To determine the effect of an ethanol-treated mid-peripheral epithelium on wound healing of the corneal epithelium. Methods Epithelial removal was performed on 18 rabbit eyes, which were divided into three groups of six eyes each as follows: group 1, an 8.0-mm diameter treated with balanced salt solution (BSS) and an 8.0-mm removal; group 2, an 8.0-mm diameter treated with 20% ethanol for 30?seconds and an 8.0-mm removal; and group 3, a 9.0-mm diameter treated with ethanol and an 8.0-mm removal (barrier zone setting group). The corneal defect area was analyzed post-operatively. The concentrations of vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) in tears were determined pre-operatively and post-operatively. Healed corneal tissues were examined with light and electron microscopy. Immunohistochemical analysis was also performed to estimate the expression of EGF receptors in healed corneal tissue. Results The epithelial healing rate in group 3 was faster than that in the two other groups (p? Conclusions The preserved mid-peripheral epithelial layer treated with ethanol (barrier zone) promoted corneal epithelial healing. It appeared to be correlated with elevated tear VEGF and EGF levels in the post-operative period.
机译：背景技术为了确定乙醇处理的中周上皮对角膜上皮伤口愈合的影响。方法对18只兔眼进行上皮摘除，分为三组，每组六只眼，分别为：第一组，经平衡盐溶液（BSS）处理的直径为8.0mm，摘除后为8.0mm。第2组，直径8.0毫米，用20％乙醇处理30秒，并去除8.0毫米。第3组，直径为9.0mm的乙醇处理和8.0mm的去除（障碍区域设置组）。术后分析角膜缺损区域。术前和术后测定眼泪中血管内皮生长因子（VEGF）和表皮生长因子（EGF）的浓度。用光和电子显微镜检查愈合的角膜组织。还进行了免疫组织化学分析，以评估愈合的角膜组织中EGF受体的表达。结果第3组的上皮愈合速度快于其他两组（p？结论）乙醇处理过的保留的中周上皮层（屏障区）促进了角膜上皮的愈合，这似乎与泪液中VEGF和泪液VEGF升高有关。术后EGF水平。

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