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首页> 外文期刊>BMC Medical Genomics >Gastric cancers of Western European and African patients show different patterns of genomic instability
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Gastric cancers of Western European and African patients show different patterns of genomic instability

机译：西欧和非洲患者的胃癌显示出不同的基因组不稳定模式

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Background Infection with H. pylori is important in the etiology of gastric cancer. Gastric cancer is infrequent in Africa, despite high frequencies of H. pylori infection, referred to as the African enigma. Variation in environmental and host factors influencing gastric cancer risk between different populations have been reported but little is known about the biological differences between gastric cancers from different geographic locations. We aim to study genomic instability patterns of gastric cancers obtained from patients from United Kingdom (UK) and South Africa (SA), in an attempt to support the African enigma hypothesis at the biological level. Methods DNA was isolated from 67 gastric adenocarcinomas, 33 UK patients, 9 Caucasian SA patients and 25 native SA patients. Microsatellite instability and chromosomal instability were analyzed by PCR and microarray comparative genomic hybridization, respectively. Data was analyzed by supervised univariate and multivariate analyses as well as unsupervised hierarchical cluster analysis. Results Tumors from Caucasian and native SA patients showed significantly more microsatellite instable tumors (p Conclusions Gastric cancers from SA and UK patients show differences in genetic instability patterns, indicating possible different biological mechanisms in patients from different geographical origin. This is of future clinical relevance for stratification of gastric cancer therapy.
机译：背景幽门螺杆菌感染在胃癌的病因中很重要。尽管幽门螺杆菌感染的频率很高，但非洲的胃癌并不常见，被称为非洲之谜。已经报道了影响不同人群之间胃癌风险的环境因素和宿主因素的变化，但是对于来自不同地理位置的胃癌之间的生物学差异知之甚少。我们旨在研究从英国（UK）和南非（SA）的患者获得的胃癌的基因组不稳定性模式，以在生物学水平上支持非洲谜团假说。方法从67例胃腺癌，33例UK患者，9例白种人SA患者和25例本地SA患者中分离DNA。通过PCR和微阵列比较基因组杂交分别分析了微卫星不稳定性和染色体不稳定性。通过有监督的单变量和多变量分析以及无监督的层次聚类分析来分析数据。结果高加索人和本地SA患者的肿瘤表现出明显更多的微卫星不稳定肿瘤（p结论来自SA和UK患者的胃癌显示出遗传不稳定模式的差异，表明来自不同地理区域的患者可能存在不同的生物学机制。这对于未来的临床意义胃癌的分层治疗。

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