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首页> 外文期刊>BMC Medical Informatics and Decision Making >Accuracy validation of adjuvant! online in Taiwanese breast cancer patients - a 10-year analysis
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Accuracy validation of adjuvant! online in Taiwanese breast cancer patients - a 10-year analysis

机译：佐剂的准确性验证！在线针对台湾乳腺癌患者进行的10年分析

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Background Adjuvant! Online ( http://www.adjuvantonline.com webcite ) is an Internet-based software program that allows clinicians to make predictions about the benefits of adjuvant therapy and 10-year survival probability for early-stage breast cancer patients. This model has been validated in Western countries such as the United States, United Kingdom, Canada, Germany, and Holland. The aim of our study was to investigate the performance and accuracy of Adjuvant! Online in a cohort of Taiwanese breast cancer patients. Methods Data on the prognostic factors and clinical outcomes of 559 breast cancer patients diagnosed at the National Cheng Kung University Hospital in Tainan between 1992 and 2001 were enrolled in the study. Comprehensive demographic, clinical outcome data, and adjuvant treatment data were entered into the Adjuvant! Online program. The outcome prediction at 10 years was compared with the observed and predicted outcomes using Adjuvant! Online. Results Comparison between low- and high-risk breast cancer patient subgroups showed significant differences in tumor grading, tumor size, and lymph node status (p?p?p?=?0.016); the predicted and observed outcomes were 21.99% and 17.46%, respectively. Conclusions Adjuvant! Online accurately predicted 10-year outcomes and assisted in decision making about adjuvant treatment in low-risk breast cancer patients in our study, although the results were less accurate in the high-risk subgroup. Development of a prognostic program based on a national database should be considered, especially for high-risk breast cancer patients in Taiwan.
机译：背景佐剂！在线（http://www.adjuvantonline.com webcite）是一个基于Internet的软件程序，可让临床医生对辅助治疗的益处以及早期乳腺癌患者的10年生存率做出预测。该模型已在美国，英国，加拿大，德国和荷兰等西方国家进行了验证。我们研究的目的是研究佐剂的性能和准确性！在台湾乳腺癌患者队列中在线。方法收集1992年至2001年在台南国立成功大学医院确诊的559例乳腺癌患者的预后因素和临床结果。全面的人口统计学，临床结果数据和辅助治疗数据已输入到佐剂中！在线程序。使用Adjuvant！将10年的结果预测与观察到的和预测的结果进行比较。线上。结果低风险和高风险乳腺癌患者亚组之间的比较显示，肿瘤分级，肿瘤大小和淋巴结状态均存在显着差异（p≥p≥p≥0.016）。预测和观察到的结果分别为21.99％和17.46％。结论佐剂！在我们的研究中，在线能够准确预测10年结局并协助制定有关低危乳腺癌患者辅助治疗的决策，尽管高危亚组的结果准确性较差。应该考虑基于国家数据库开发预后程序，尤其是对于台湾的高危乳腺癌患者。

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