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首页> 外文期刊>BMC Medical Informatics and Decision Making >X-search: an open access interface for cross-cohort exploration of the National Sleep Research Resource
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X-search: an open access interface for cross-cohort exploration of the National Sleep Research Resource

机译：X-search：一个开放式访问界面，用于跨队列研究国家睡眠研究资源

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The National Sleep Research Resource (NSRR) is a large-scale, openly shared, data repository of de-identified, highly curated clinical sleep data from multiple NIH-funded epidemiological studies. Although many data repositories allow users to browse their content, few support fine-grained, cross-cohort query and exploration at study-subject level. We introduce a cross-cohort query and exploration system, called X-search, to enable researchers to query patient cohort counts across a growing number of completed, NIH-funded studies in NSRR and explore the feasibility or likelihood of reusing the data for research studies. X-search has been designed as a general framework with two loosely-coupled components: semantically annotated data repository and cross-cohort exploration engine. The semantically annotated data repository is comprised of a canonical data dictionary, data sources with a data dictionary, and mappings between each individual data dictionary and the canonical data dictionary. The cross-cohort exploration engine consists of five modules: query builder, graphical exploration, case-control exploration, query translation, and query execution. The canonical data dictionary serves as the unified metadata to drive the visual exploration interfaces and facilitate query translation through the mappings. X-search is publicly available at https://www.x-search.net/ with nine NSRR datasets consisting of over 26,000 unique subjects. The canonical data dictionary contains over 900 common data elements across the datasets. X-search has received over 1800 cross-cohort queries by users from 16 countries. X-search provides a powerful cross-cohort exploration interface for querying and exploring heterogeneous datasets in the NSRR data repository, so as to enable researchers to evaluate the feasibility of potential research studies and generate potential hypotheses using the NSRR data.
机译：国家睡眠研究资源（NSRR）是来自多个NIH资助的流行病学研究的，身份不明的高度精选的临床睡眠数据的大规模，开放共享的数据库。尽管许多数据存储库都允许用户浏览其内容，但很少有人支持研究对象级别的细粒度，跨队列查询和探索。我们引入了跨队列查询和探索系统，称为X-search，以使研究人员可以查询越来越多的，由NIH资助的NSRR研究中越来越多的患者队列计数，并探索将数据重新用于研究的可行性或可能性。 。 X-search被设计为具有两个松散耦合组件的通用框架：语义注释的数据存储库和跨队列探索引擎。带有语义注释的数据存储库由规范数据字典，具有数据字典的数据源以及每个单独的数据字典与规范数据字典之间的映射组成。跨队列浏览引擎包括五个模块：查询构建器，图形浏览，案例控制浏览，查询翻译和查询执行。规范数据字典用作统一元数据，以驱动可视浏览界面并通过映射促进查询翻译。 X-search可以在https://www.x-search.net/上公开获得，其中包含9个NSRR数据集，其中包括26,000多个独立主题。规范数据字典包含整个数据集中的900多个通用数据元素。 X-search已收到来自16个国家/地区的用户的1800多个跨队列查询。 X-search提供了强大的跨队列探索界面，用于查询和探索NSRR数据存储库中的异构数据集，从而使研究人员能够评估潜在研究的可行性并使用NSRR数据生成潜在假设。

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