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首页> 外文期刊>BMC Ophthalmology >Risk factors for open-angle glaucoma in Nigeria: results from the Nigeria National Blindness and Visual Impairment Survey
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Risk factors for open-angle glaucoma in Nigeria: results from the Nigeria National Blindness and Visual Impairment Survey

机译：尼日利亚开角型青光眼的危险因素：尼日利亚全国失明和视力障碍调查的结果

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Background The glaucoma-specific blindness prevalence in Nigeria (0.7?%, 95 % CI 0.6–0.9?%) among those aged ≥40?years is one of the highest ever reported. This study determined the risk factors for open-angle glaucoma (OAG) in adults examined in the Nigeria National Blindness and Visual Impairment Survey. Methods A nationally representative sample of 13,591 people aged ≥40?years in 305 clusters in Nigeria were examined (response rate 90.4?%) between January 2005 to June 2007. Everyone had logMAR visual acuity measurement, Frequency Doubling Technology (FDT) visual field testing, autorefraction, A-scan biometry and optic disc assessment. Full ocular examination ( n =?6397), included Goldmann applanation tonometry. Values for defining glaucoma using International Society of Geographical and Epidemiological Ophthalmology criteria were derived from the study population. Disc images were graded by Moorfields Eye Hospital Reading Centre. Socio-demographic factors (age, gender, ethnicity, literacy and place of residence), ocular parameters (intraocular pressure [IOP], axial length and mean ocular perfusion pressure [MOPP]) and systemic parameters (blood pressure, blood glucose and body mass index [BMI]) were assessed for association with OAG. Results Thirteen thousand eighty-one (96?%) of 13,591 participants had vertical cup:disc ratio measured in at least one eye. 682 eyes of 462 participants were classified as OAG, with 12,738 controls. In univariate analyses the following were associated with OAG: increasing age, male gender, Igbo and Yoruba ethnic groups, illiteracy, longer axial length, higher IOP, lower MOPP, greater severity of hypertension and low BMI (underweight). In multivariate analysis, increasing age (odds ratio [OR] 1.04, 95 % CI 1.03–1.05), higher IOP (OR 1.22, 95 % CI 1.18–1.25) and Igbo ethnicity (OR 1.73, 95 % CI 1.18–2.56) were independent risk factors for OAG. Conclusion Case detection strategies for OAG should be improved for those aged ≥40?years and for ethnic groups most at risk as a public health intervention.
机译：背景≥40岁的人群中，尼日利亚的青光眼特异性失明患病率（0.7％，95％CI为0.6-0.9％）是有史以来报道的最高之一。这项研究确定了在尼日利亚全国失明和视力障碍调查中检查的成人开角型青光眼（OAG）的危险因素。方法对2005年1月至2007年6月在尼日利亚的305个集群中年龄≥40岁的13591人进行了全国代表性抽样调查（回应率为90.4％）。每个人都进行了logMAR视力测量，倍频技术（FDT）视野测试。 ，自动验光，A扫描生物测定法和视盘评估。全面的眼部检查（n =？6397），包括戈德曼压平眼压计。使用国际地理和流行病学眼科协会标准定义青光眼的值来自研究人群。光盘图像由Moorfields眼科医院阅读中心分级。社会人口统计学因素（年龄，性别，种族，文化程度和居住地），眼参数（眼压[IOP]，轴向长度和平均眼灌注压[MOPP]）和系统参数（血压，血糖和体重）指数[BMI]）与OAG相关联。结果13,591名参与者中的1.38万名（96％）具有至少一只眼睛测量的垂直杯碟比。 462名参与者中的682只眼被归类为OAG，具有12,738名对照。在单变量分析中，以下因素与OAG相关：年龄增长，男性，伊博族和约鲁巴族，文盲，更长的轴长，更高的IOP，更低的MOPP，高血压的严重程度和BMI偏低（体重不足）。在多变量分析中，年龄增加（赔率[OR] 1.04，95％CI 1.03–1.05），更高的IOP（OR 1.22，95％CI 1.18–1.25）和Igbo族裔（OR 1.73，95％CI 1.18–2.56） OAG的独立危险因素。结论对于年龄≥40岁的人群和作为公共卫生干预措施风险最大的种族，应改进OAG的病例检测策略。

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