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首页> 外文期刊>BMC nutrition. >Higher bioavailability of magnesium citrate as compared to magnesium oxide shown by evaluation of urinary excretion and serum levels after single-dose administration in a randomized cross-over study
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Higher bioavailability of magnesium citrate as compared to magnesium oxide shown by evaluation of urinary excretion and serum levels after single-dose administration in a randomized cross-over study

机译：在随机交叉研究中，单次给药后评估尿排泄和血清水平，与氧化镁相比，柠檬酸镁具有更高的生物利用度

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BackgroundThe development of several disorders, such as cardiovascular diseases, diabetes and osteoporosis, has been linked to suboptimal dietary magnesium (Mg) intake. In this context, a number of studies have tried to investigate which Mg compounds are best suited for Mg supplementation. Results suggest that organic Mg compounds are superior to the inorganic Mg oxide in terms of bioavailability, but a reliable statement cannot yet be made due to systematic differences in the applied study designs. MethodsThis single-center, randomized, open, 2-period, 2-supplementation, 2-sequence, single-dose, cross-over study was conducted in 20 healthy male subjects of Caucasian origin to investigate and compare the bioavailability of Mg citrate, an organic Mg compound, and Mg oxide, an inorganic Mg compound. In order to reliably assess the bioavailability of both Mg compounds, subjects were supplemented with magnesium to saturate their Mg-pools before administration of each study product. The bioavailability of both Mg compounds was then assessed by measurement of the renally eliminated Mg quantity during an interval of 24?h after single-dose Mg administration (Ae 0-24h) as primary endpoint. Additionally, the Mg concentrations in a subset of leukocytes, in erythrocytes and in serum were measured on an exploratory basis. ResultsAfter administration, Ae 0-24h of magnesium was higher for Mg citrate than for Mg oxide. Ae 0-24h for both study products was compared by analysis of variance (ANOVA), revealing an adjusted mean difference of 0.565?mmol, which was statistically significant at the 5% level (95% confidence interval of 0.212 to 0.918?mmol, p =?0.0034). Besides, serum Mg concentrations were statistically significantly higher for Mg citrate than for Mg oxide at several time points after administration. No statistically significant difference was shown in intracellular Mg contents. ConclusionsThis study confirms former study results showing a higher bioavailability of the organic Mg compound Mg citrate compared to Mg oxide. It can be concluded that Mg citrate, similar to other organic Mg compounds, may be more suitable than Mg oxide to optimize the dietary magnesium intake. Trial registrationRetrospectively registered with the Australian New Zealand Clinical Trials Registry ( ACTRN12615001268538 ) on November 19, 2015.
机译：背景技术几种疾病的发展，例如心血管疾病，糖尿病和骨质疏松症，与饮食中镁（Mg）摄入不足有关。在这种情况下，许多研究试图研究哪种镁化合物最适合补充镁。结果表明，有机镁化合物在生物利用度方面优于无机氧化镁，但由于在应用研究设计中存在系统差异，因此尚不能做出可靠的陈述。方法：这项单中心，随机，开放，2周期，2补充，2序列，单剂量，交叉研究是在20名高加索裔健康男性男性中进行的，以调查和比较柠檬酸镁（一种生物碱）的生物利用度。有机镁化合物和氧化镁，无机镁化合物。为了可靠地评估两种Mg化合物的生物利用度，在给予每种研究产品之前，向受试者补充镁以使其Mg池饱和。然后通过以单剂量Mg给药（A 0-24h ）作为主要终点，在24小时内测量肾脏消除的Mg量，评估两种Mg化合物的生物利用度。另外，在探索性基础上测量白细胞子集中，红细胞和血清中的Mg浓度。结果给药后，柠檬酸镁的A 高于氧化镁。通过方差分析（ANOVA）比较两种研究产品的A e 0-24h ，发现调整后的均值差为0.565？mmol，在5％水平（95％置信区间为统计上显着） 0.212至0.918≤mmol，p ＝≤0.0034）。此外，在给药后的几个时间点，柠檬酸镁的血清镁浓度在统计学上显着高于氧化镁。细胞内镁含量未显示统计学上的显着差异。结论这项研究证实了以前的研究结果，表明有机Mg化合物柠檬酸Mg的生物利用度高于氧化镁。可以得出结论，与其他有机Mg化合物相似，柠檬酸Mg可能比氧化Mg更适合于优化饮食中镁的摄入。试验注册于2015年11月19日在澳大利亚新西兰临床试验注册中心（ACTRN12615001268538）进行了追溯注册。

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