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首页> 外文期刊>BMC Endocrine Disorders >Exploring the potential association between brominated diphenyl ethers, polychlorinated biphenyls, organochlorine pesticides, perfluorinated compounds, phthalates, and bisphenol a in polycystic ovary syndrome: a case-control study
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Exploring the potential association between brominated diphenyl ethers, polychlorinated biphenyls, organochlorine pesticides, perfluorinated compounds, phthalates, and bisphenol a in polycystic ovary syndrome: a case-control study

机译：探索溴化二苯醚，多氯联苯，有机氯农药，全氟化合物，邻苯二甲酸酯和双酚a在多囊卵巢综合征中的潜在关联：病例对照研究

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Background Polycystic Ovary Syndrome (PCOS) is an endocrine-metabolic disorder that affects approximately 6-10% of women of child-bearing age. Although preliminary studies suggest that certain pollutants may act as endocrine disruptors in animals, little is known about their potential association with PCOS. The objective of this case-control pilot study is to determine whether women with PCOS have higher concentrations of specific environmental contaminants compared to women who have not developed PCOS. Methods Fifty-two PCOS case-patients (diagnosed using the National Institutes of Health 1990 definition) and 50 controls were recruited in 2007–2008, from an urban academic medical center in Los Angeles, CA. Brominated diphenyl ethers, polychlorinated biphenyls (PCBs), organochlorine pesticides, and perfluorinated compounds (PFCs) were measured in serum, and phthalates metabolites and bisphenol A (BPA) in urine. Results PCOS case-patients had significantly higher geometric mean (GM) serum concentrations of two PFCs: perfluorooctanoate (PFOA) (GMcases = 4.1 μg/L, GMcontrols = 2.3 μg/L; p = 0.001) and perfluorooctane sulfonate (PFOS) (GMcases = 8.2 μg/L, GMcontrols = 4.9 μg/L; p = 0.01), and lower urinary concentrations of monobenzyl phthalate (mBzP) (GMcases = 7.5 μg/g creatinine, GMcontrols = 11.7 μg/g creatinine; p = 0.02). Logistic regression, controlling for body mass index, age and race, identified an increased likelihood of PCOS in subjects with higher serum concentrations of PFOA and PFOS (adjusted-ORs = 5.8–6.9, p < 0.05), and with lower urine concentrations of mBzP and mono-n-butyl phthalate (mBP) (aORs = 0.14–0.25, p < 0.05). Conclusions Our data suggest that PCOS case-patients may differ from controls in their environmental contaminant profile. PCOS subjects had higher serum concentrations of two PFCs, PFOA and PFOS, and lower urine concentrations of mBP and mBzP. Future studies are needed to confirm these preliminary findings and determine if these chemicals or their precursors may have a role in the pathogenesis of PCOS.
机译：背景多囊卵巢综合症（PCOS）是一种内分泌代谢紊乱，影响大约6-10％的育龄妇女。尽管初步研究表明某些污染物可能会在动物体内充当内分泌干扰物，但对其与PCOS的潜在关联知之甚少。该病例对照试验研究的目的是确定患有PCOS的女性与未患PCOS的女性相比是否具有较高的特定环境污染物浓度。方法2007年至2008年，从加利福尼亚州洛杉矶市的一个城市学术医疗中心招募了52例PCOS病例患者（使用美国国立卫生研究院1990年的定义进行诊断）和50例对照。测定血清中的溴化二苯醚，多氯联苯（PCB），有机氯农药和全氟化合物（PFC），以及尿液中的邻苯二甲酸酯代谢物和双酚A（BPA）。结果PCOS病例患者的两种PFC的几何平均（GM）血清浓度显着更高：全氟辛酸（PFOA）（GMcases = 4.1μg/ L，GMcontrols = 2.3μg/ L; p = 0.001）和全氟辛烷磺酸（PFOS） = 8.2μg/ L，GMcontrols = 4.9μg/ L; p = 0.01）和较低的尿中邻苯二甲酸单苄酯（mBzP）浓度（GMcases = 7.5μg/ g肌酐，GMcontrols = 11.7μg/ g肌酐; p = 0.02）。逻辑回归，控制体重指数，年龄和种族，确定了血浆中PFOA和PFOS浓度较高（校正OR值为5.8–6.9，p <0.05）且尿液中mBzP浓度较低的受试者中PCOS的可能性增加和邻苯二甲酸单正丁酯（mBP）（aORs = 0.14-0.25，p <0.05）。结论我们的数据表明，PCOS病例患者的环境污染物状况可能与对照组不同。 PCOS受试者的两种PFC，PFOA和PFOS的血清浓度较高，而mBP和mBzP的尿液浓度较低。需要进一步的研究来确认这些初步发现，并确定这些化学物质或其前体是否可能在PCOS的发病机理中起作用。

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