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首页> 外文期刊>BMC Ophthalmology >Use of Mitomycin C to reduce the incidence of encapsulated cysts following ahmed glaucoma valve implantation in refractory glaucoma patients: a new technique
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Use of Mitomycin C to reduce the incidence of encapsulated cysts following ahmed glaucoma valve implantation in refractory glaucoma patients: a new technique

机译：丝裂霉素C减少难治性青光眼患者接受艾氏青光眼瓣膜植入术后囊肿囊肿的发生：一项新技术

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Background To evaluate the surgical outcome of Ahmed glaucoma valve (AGV) implantation with a new technique of mitomycin C (MMC) application. Methods This is a retrospective study. All patients with refractory glaucoma underwent FP-7 AGV implantation. Two methods of MMC application were used. In the traditional technique, 6?×?4?mm cotton soaked with MMC (0.25–0.33?mg/ml) was placed in the implantation area for 2–5mins; in the new technique, the valve plate first was encompassed with a thin layer of cotton soaked with MMC, then inserted into the same area. A 200?ml balanced salt solution was applied for irrigation of MMC. The surgical success rate, intraocular pressure (IOP), number of anti-glaucoma medications used, and postoperative complications were analyzed between the groups. Results The surgical outcomes of two MMC applied techniques were compared. The new technique group had only one case (2.6%) of encapsulated cyst formation out of 38 eyes, while there were eight (19.5%) cases out of 41 eyes the in traditional group. The difference was statistically significant (P?=?0.030). According to the definition of success rate, there was 89.5% in the new technique group and 70.7% in the traditional group at the follow-up end point. There was a significant difference between the two groups (P?=?0.035). Mean IOP in the new technique group were significantly lower than those of the traditional group at 3 and 6?months (P? Conclusions By using a thin layer of cotton soaked with MMC to encompass the valve plate, the new MMC application technique could greatly decrease the incidence of encapsulated cyst and increase the success rate following AGV implantation.
机译：背景技术使用丝裂霉素C（MMC）新技术评估艾哈迈德青光眼瓣膜（AGV）植入的手术效果。方法这是一项回顾性研究。所有难治性青光眼患者均接受FP-7 AGV植入。使用了两种MMC应用方法。在传统技术中，将6×××4μm棉花（MMC浸透量为0.25-0.33μg/ ml）放置在植入区域2-5分钟。在新技术中，先将阀板覆盖一层薄薄的MMC浸透的棉花，然后再将其插入相同的区域。 200毫升的平衡盐溶液用于MMC的灌溉。分析两组之间的手术成功率，眼压（IOP），使用的抗青光眼药物的数量以及术后并发症。结果比较了两种MMC应用技术的手术效果。新技术组在38眼中只有1例（2.6％）囊肿形成囊肿，而在传统组中41眼中有8例（19.5％）。差异具有统计学意义（P≤0.030）。根据成功率的定义，在随访终点，新技术组为89.5％，传统组为70.7％。两组之间有显着差异（P≥0.035）。新技术组在3个月和6个月时的平均IOP显着低于传统组（P？结论）通过使用一层薄薄的MMC浸透的棉布覆盖阀板，新的MMC应用技术可以大大降低AGV植入后囊肿囊肿的发生率增加，成功率提高。

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