...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BMC Genetics >Characterizing a region on BTA11 affecting β-lactoglobulin content of milk using high-density genotyping and haplotype grouping
【24h】

Characterizing a region on BTA11 affecting β-lactoglobulin content of milk using high-density genotyping and haplotype grouping

机译：使用高密度基因分型和单倍型分组表征BTA11上影响牛奶中β-乳球蛋白含量的区域

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Milk β-lactoglobulin (β-LG) content is of interest as it is associated with nutritional and manufacturing properties. It is known that milk β-LG content is strongly affected by genetic factors. In cattle, most of the genetic differences are associated with a chromosomal region on BTA11, which contains the β-LG gene. The aim of this study was to characterize this region using 777?k SNP data (BovineHDbeadChip) and perform a haplotype-based association study. A statistical approach was developed to build haplotypes that capture the genetic variation associated with this genomic region. Results The SNP with the most significant effect on β-lactoglobulin content was one of the 2 causal mutations responsible for the β-lactoglobulin protein variants A/B. Haplotypes based on 2 to 5 selected lead SNP were clustered in groups with different effects on β-lactoglobulin content. Four different groups were identified suggesting that β-lactoglobulin variant A and B can be further refined in A1, A2, B1 and B2. Conclusions This study showed that β-lactoglobulin protein variants A/B do not explain all genetic variation associated with the tail part of BTA11 but this region contains more than one mutation with an effect on β-lactoglobulin content. These findings can be used for selection of cows with higher cheese yield, which is desirable for the dairy industry.
机译：背景牛奶中的β-乳球蛋白（β-LG）含量令人关注，因为它与营养和制造特性有关。众所周知，牛奶中的β-LG含量受遗传因素的强烈影响。在牛中，大多数遗传差异与BTA11上的一个染色体区域有关，该区域包含β-LG基因。这项研究的目的是使用777？k SNP数据（BovineHDbeadChip）表征该区域并进行基于单体型的关联研究。开发了一种统计方法来构建单倍型，以捕获与此基因组区域相关的遗传变异。结果对β-乳球蛋白含量影响最大的SNP是导致β-乳球蛋白蛋白变异A / B的2个因果突变之一。基于2至5个所选先导SNP的单倍型聚集在对β-乳球蛋白含量有不同影响的组中。确定了四个不同的组，这表明可以在A 1 ，A 2 ，B 1 和B中进一步完善β-乳球蛋白变体A和B。 2 。结论这项研究表明，β-乳球蛋白蛋白变体A / B不能解释与BTA11尾部有关的所有遗传变异，但是该区域包含一个以上的突变，对β-乳球蛋白的含量有影响。这些发现可用于选择奶酪产量更高的奶牛，这对于乳业来说是理想的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号