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首页> 外文期刊>BMC Gastroenterology >The diagnostic value of pepsin detection in saliva for gastro-esophageal reflux disease: a preliminary study from China
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The diagnostic value of pepsin detection in saliva for gastro-esophageal reflux disease: a preliminary study from China

机译：胃蛋白酶检测在唾液中对胃食管反流病的诊断价值：来自中国的初步研究

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None of current diagnostic methods has been proven to be a reliable tool for gastro-esophageal reflux disease (GERD). Pepsin in saliva has been proposed as a promising diagnostic biomarker for gastro-esophageal reflux. We aimed to determine the diagnostic value of salivary pepsin detection for GERD. Two hundred and fifty patients with symptoms suggestive of GERD and 35 asymptomatic healthy volunteers provided saliva on morning waking, after lunch and dinner for pepsin determination using the Peptest lateral flow device. All patients underwent 24-h multichannel intraluminal impedance pH (24-h MII-pH) monitoring and upper gastrointestinal endoscopy. Based on 24-h MII-pH and endoscopy study, patients were defined as GERD (abnormal MII-pH results and/or reflux esophagitis) and non-GERD otherwise. Patients with GERD had a higher prevalence of pepsin in saliva and higher pepsin concentration than patients with non-GERD and healthy controls (P < 0.001 for all). The pepsin test had a sensitivity of 73% and a specificity of 88.3% for diagnosing GERD using the optimal cut-off value of 76?ng/mL. Postprandial saliva samples collected when the symptoms occurred had a more powerful ability to identify GERD. Salivary pepsin test had moderate diagnostic value for GERD. It may be a promising tool to replace the use of currently invasive tools with advantages of non-invasive, easy to perform and cost effective. ChiCTR-DDD-16009506 (date of registration: October 20, 2016).
机译：目前的诊断方法均未被证明是解决胃食管反流疾病（GERD）的可靠工具。唾液中的胃蛋白酶已被提出作为胃食管反流的有前途的诊断生物标志物。我们旨在确定唾液胃蛋白酶检测对GERD的诊断价值。 250名症状提示GERD的患者和35名无症状的健康志愿者在早晨醒来时提供午餐，午餐和晚餐后使用Peptest横向流动装置测定胃蛋白酶。所有患者均接受24小时多通道管腔内阻抗pH（24-h MII-pH）监测和上消化道内镜检查。根据24小时MII-pH和内窥镜检查研究，将患者定义为GERD（MII-pH结果异常和/或反流性食管炎），否则为非GERD。与非GERD和健康对照组相比，GERD患者唾液中胃蛋白酶的患病率更高，胃蛋白酶浓度更高（所有患者的P <0.001）。胃蛋白酶测试的最佳临界值为76？ng / mL，诊断GERD的敏感性为73％，特异性为88.3％。出现症状时收集的餐后唾液样本具有更强的GERD识别能力。唾液胃蛋白酶测试对GERD有中等诊断价值。用非侵入性，易于执行且具有成本效益的优点来代替使用当前侵入性工具可能是一种有前途的工具。 ChiCTR-DDD-16009506（注册日期：2016年10月20日）。

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