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首页> 外文期刊>Beilstein journal of organic chemistry. >Pyrene-modified PNAs: Stacking interactions and selective excimer emission in PNA2DNA triplexes
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Pyrene-modified PNAs: Stacking interactions and selective excimer emission in PNA2DNA triplexes

机译：yr修饰的PNA：PNA2DNA三元体中的堆积相互作用和选择性准分子发射

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Pyrene derivatives can be incorporated into nucleic acid analogs in order to obtain switchable probes or supramolecular architectures. In this paper, peptide nucleic acids (PNAs) containing 1 to 3 1-pyreneacetic acid units ( PNA1 – 6 ) with a sequence with prevalence of pyrimidine bases, complementary to cystic fibrosis W1282X point mutation were synthesized. These compounds showed sequence-selective switch-on of pyrene excimer emission in the presence of target DNA, due to PNA2DNA triplex formation, with stability depending on the number and positioning of the pyrene units along the chain. An increase in triplex stability and a very high mismatch-selectivity, derived from combined stacking and base-pairing interactions, were found for PNA2 , bearing two distant pyrene units.
机译：可以将衍生物掺入核酸类似物中以获得可切换的探针或超分子结构。在本文中，合成了含有1至3个1-丙氨酸乙酸单位（PNA1 – 6）的肽核酸（PNAs），其序列具有嘧啶碱基的普遍性，与囊性纤维化W1282X点突变互补。由于PNA 2 DNA三链体的形成，这些化合物在目标DNA存在下显示出showed准分子发射的序列选择性开启，其稳定性取决于the单元沿链的数量和位置。对于携带两个遥远的pyr单元的PNA2，发现了三元体稳定性的提高和非常高的错配选择性，这是由组合的堆积和碱基配对相互作用共同产生的。

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