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首页> 外文期刊>BMJ Open Respiratory Research >CNS imaging studies in cystic fibrosis patients presenting with sudden neurological events
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CNS imaging studies in cystic fibrosis patients presenting with sudden neurological events

机译：中枢神经系统影像学研究在患有突然神经系统事件的囊性纤维化患者中的应用

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Background Acute neurological events may present as an extrapulmonary complication in patients with cystic fibrosis (CF). These events can be secondary to a range of different aetiologies.Methods A retrospective analysis of 476 medical records of CF patients attending a large teaching hospital between 2000 and 2018 was performed. Patients presenting with acute neurological events who had MRI brain imaging were evaluated. Patients who had headaches without associated neurological symptoms were excluded from this analysis.Results Acute neurological presentations, excluding headaches without associated neurological symptoms, were reported in 27 index patients out of the 476 patients. Of these, 16 patients had MRI brain imaging for review. Three patients suffered pathology secondary to vascular events, both ischaemic and haemorrhagic; four patients had evidence of ischaemia or infarction not consistent with a vascular territory stroke and the remaining patients experienced a range of different neurological events. The most common presentation among these patients was seizure activity, followed by a transient motor or sensory deficit.Conclusions Neurological complications are recognised among individuals with CF. Although rare, they can be secondary to a range of different aetiologies, including dysfunctional cell energetics. Additional studies are required to further evaluate this association.
机译：背景患有囊性纤维化（CF）的患者，急性神经系统事件可能表现为肺外并发症。这些事件可能是由各种病因引起的。方法对2000年至2018年间在大型教学医院就诊的CF患者的476份病历进行回顾性分析。对表现出急性神经系统事件并进行了MRI脑成像的患者进行了评估。结果分析476例患者中有27例报告了急性神经系统表现，不包括无神经症状的头痛。其中，有16位患者接受了MRI脑成像检查。 3例患者因缺血性和出血性血管事件而继发病理。四名患者有局部缺血或梗塞的证据与血管性中风不一致，其余患者经历了一系列不同的神经系统事件。在这些患者中，最常见的表现是癫痫发作，随后是短暂的运动或感觉障碍。结论CF患者有神经系统并发症。尽管很少见，但它们可能是多种病因引起的，包括细胞功能异常。需要进一步的研究以进一步评估这种关联。

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